177219-40-8

Usage

Uses

Used in Organic Chemistry:
1-Pentanoylamino-cyclopentane carboxylic acid is used as a synthetic intermediate for the preparation of various organic compounds. Its unique structure allows for the formation of diverse chemical entities through reactions such as esterification, amidation, and other functional group transformations.
Used in Pharmaceutical Industry:
1-Pentanoylamino-cyclopentane carboxylic acid is used as a potential candidate for the development of new drugs. Its structural features may contribute to the design of novel therapeutic agents with specific biological activities. Further research and optimization are required to explore its full potential in drug discovery.
Used in Other Industrial Processes:
1-Pentanoylamino-cyclopentane carboxylic acid may also find applications in various industrial processes, such as the synthesis of specialty chemicals, materials, or as a component in formulations. Its versatility and reactivity make it a valuable compound for exploring new applications in different industries.
Safety Considerations:
It is important to handle 1-pentanoylamino-cyclopentane carboxylic acid with care and follow proper safety protocols, as it may have specific hazards associated with its use. This includes taking necessary precautions during storage, handling, and disposal to minimize risks to human health and the environment.

Upstream product

• 194984-24-2 1-cyano-1-n-pentanoylaminocyclopentane 
• 17193-28-1 1-aminocyclopentane-1-carboxamide 
• 638-29-9 n-valeryl chloride 

Downstream Products

• 141745-71-3 1-pentanoylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide 
• 138402-05-8 2-butyl-1,3-diaza-spiro[4.4]non-1-en-4one 
• 908227-87-2 2-butyl-3-(4'-iodobenzyl)-1,3-diazaspiro[4,4]non-1-en-4-one 
• 138402-10-5 trityl irbesartan 

Relevant academic research and scientific papers

Design, synthesis and evaluation of novel potent angiotensin II receptor 1 antagonists

A series of new angiotensin II (Ang II) receptor 1 antagonists were designed, synthesized and evaluated. All compounds showed nanomolar affinities for the angiotensin II type 1 receptor in radioligand binding assays and could reduce blood pressure signifi

A new process for the preparation of irbesartan

A process for the preparation of Irbesartan or a pharmaceutically acceptable salt thereof comprising the step of coupling the 1-pentanamidocyclapentanecarboxamide of formula (V) with 4'-substituted methyl biphenyl-2-carbonitrile or 1-(4'-substituted methyl biphenyl-2-yl)-1H-tetrazole wherein tetrazole can be protected or unprotected to obtain the N-[(2'-cyanobiphenyl-4-yl)methyl]-1-pentanamidocyclopentanecarboxamide or N-[1-({[2'-(1H-tetrazol-1-yl)biphenyl-4-yl]methylamino)methyl)cydopentyl]pentanamide wherein tetrazole can be protected or unprotected that is further processed to Irbesartan or a pharmaceutical acceptable salt thereof.

SYNTHESIS OF 2-BUTYL-3-(2'-(1-TRITYL-1H-TETRAZOL-5-YL)BIPHENYL-4-YL)-1,3-DIAZASPIROL[4,4]-NON-ENE-4-ONE

Provided is a novel method of making 2-butyl-3-[[2'(1-trityl-1H-tetrazol-5-yl)biphen-4-yl]methyl]1,3-diazaspiro[4,4]non-1-ene-4-one, which can be converted to irbesartan. Also provided are methods of making irbesartan.

Preparation of acylated α-amino carboxylic acid amides

A method of preparing acylated α-amino carboxylic acid amides directly from amino nitriles in high yield and purity. The method involves acylating the amino nitrile with an acyl halide under Schotten-Baumann conditions, and hydrolyzing the resulting nitrile to the amide. The resulting acylated amino carboxylic acid amide precipitates and can be isolated by filtration in high purity.

Method of treating or preventing cardiac arrhythmia employing an N-substituted heterocyclic derivative

The invention relates to the use of an N-substituted heterocyclic derivative and its pharmaceutically acceptable salts for the treatment or prevention of cardiac arrhythmia. These derivatives have the structure STR1

N-SUBSTITUTED HETEROCYCLIC DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS IN WHICH THEY ARE PRESENT

The invention relates to N-substituted heterocyclic derivatives and its salts. These derivatives have the formula (I) in which the substituents are as defined in the specification. Application: Angiotensin II antagonists