17722-35-9Relevant academic research and scientific papers
Compositions for Treating Hyperproliferative Vascular Disorders and Cancers
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, (2010/06/11)
The present invention relates to a pharmaceutical composition for preventing or treating hyperproliferative vascular disorders, and a pharmaceutical anticancer composition comprising the compound represented by the Formula 1. The present compounds exhibit IC50 values of less than 0.16 μM for vascular smooth muscle cells and cancer cells to effectively prevent proliferation of vascular smooth muscle cells and cancer cells, thereby ensuring prevention or treatment of hyperproliferative vascular disorders such as arteriosclerosis and restenosis, and cancers.
Isopropyl N-arylmalonamates. Synthesis, structure, conformation and reactions with carbon disulfide
Rudorf, Wolf-Dieter,Loos, Dusan,Wybraniec, Joanna,Pronayova, Nad'a,Gawinecki, Ryszard,Sustekova, Zora
, p. 59 - 76 (2007/10/03)
Acylation of aromatic amines 1 with diisopropyl malonate (2) leads to a mixture of isopropyl N-arylmalonamates 3 and malonanilides 4. The reaction of 3 with carbon disulfide in the presence of sodium hydride gives disodium salts 5. Treatment of 5 with an alkylating agent yields the open-chain or cyclic ketene dithioacetals 6, 7 or 8. The molecular structure, hydrogen bonding and preferential conformation of the isopropyl N-arylmalonamates 3, 6 and 7 were investigated using correlation analyses of IR, 13C NMR and AMI semiempirical data.
Synthesis of Benzo-halogenated 4-Hydroxy-2(1H)-quinolones
Kappe, Thomas,Karem, Abdel S.,Stadlbauer, Wolfgang
, p. 857 - 862 (2007/10/02)
Malondianilides 3 derived from dichloro substituted anilines 2 undergo cyclization to afford 4-hydroxy-2(1H)-quinolones 4 in very good yields using methane sulfonic acid-phosphorus pentoxide as catalyst. 3,4-Dichloro anilines 5 can be shown to yield two i
Reaction of malondiamides with disulfur dichloride: a reinvestigation
Kutney, Gerald W.,Still, Ian W.J.
, p. 1233 - 1238 (2007/10/02)
The reaction of a series of N,N'-dialkyl and N,N'-diaryl malondiamides with disulfur dichloride have been reinvestigated.The claim, made almost 60 years ago, that the products of this reaction are dithioketones R2CS2, is shown to be unfounded.The structures of these products are shown to be the symmetrically substituted 1,2,4,5-tetrathianes, 8a-e.-
