17722-76-8

Basic information

• Product Name: 4-((4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)AMINO)-4-OXOBUTANOIC ACID
• Synonyms: 4-((4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)AMINO)-4-OXOBUTANOIC ACID
• CAS NO: 17722-76-8
• Molecular Formula: C₁₁H₉ClF₃NO₃
• Molecular Weight: 295.6422696
• Mol File: 17722-76-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-((4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)AMINO)-4-OXOBUTANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)AMINO)-4-OXOBUTANOIC ACID(17722-76-8)
• EPA Substance Registry System: 4-((4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)AMINO)-4-OXOBUTANOIC ACID(17722-76-8)

Safety Data

• Hazardous Substances Data: 17722-76-8(Hazardous Substances Data)

Upstream product

• 108-30-5 succinic acid anhydride 
• 320-51-4 4-chloro-3-trifluoromethyl-aniline 

Downstream Products

• 23115-76-6 (C₄H₉)3SnOOCCH₂CH₂CONHC₆H₃(CF₃)Cl 

Relevant articles and documents

Synthesis method of 2,2'-bis(trifluoromethyl)-4,4'-diaminobiphenyl

The invention discloses a synthesis method of 2,2'-bis(trifluoromethyl)-4,4'-diaminobiphenyl. The method comprises the following steps: subjecting 2-chloro-5-aminobenzotrifluoride serving as a starting raw material and acyclic anhydride in a formula I to amidation to obtain an intermediate II, then carrying out reductive coupling reaction on the intermediate II to obtain an intermediate III, and finally carrying out deamidation reaction on the intermediate III to obtain the 2,2'-bis(trifluoromethyl)-4,4'-diaminobiphenyl, wherein the cyclic anhydride in the formula I is succinic anhydride, glutaric anhydride, adipic anhydride or maleic anhydride. The starting material 2-chloro-5-aminobenzotrifluoride is an important farm chemical and medical intermediate, and is low in price, convenient and easy to obtain; the synthesis route is short, the reaction condition is mild, and the method is environment-friendly; the total yield of the synthetic route can reach 60-80%, and compared with the prior art, the synthetic route has obvious advantages and is suitable for industrial mass production.