17726-03-3

Basic information

• Product Name: 1,2-dimethyl-1H-indole-3-ethylamine
• Synonyms: 1,2-dimethyl-1H-indole-3-ethylamine;1,2-Dimethyl-1H-indole-3-(ethanamine);1,2-Dimethyl-3-(2-aminoethyl)-1H-indole;3-(2-Aminoethyl)-1,2-dimethyl-1H-indole;1H-Indole-3-ethanamine, 1,2-dimethyl-;Einecs 241-721-2
• CAS NO: 17726-03-3
• Molecular Formula: C₁₂H₁₆N₂
• Molecular Weight: 188.26884
• EINECS: 241-721-2
• Mol File: 17726-03-3.mol

Chemical Properties

• Boiling Point: 348°Cat760mmHg
• Flash Point: 164.2°C
• Appearance: /
• Density: 1.07g/cm³
• Vapor Pressure: 5.2E-05mmHg at 25°C
• Refractive Index: 1.581
• CAS DataBase Reference: 1,2-dimethyl-1H-indole-3-ethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-dimethyl-1H-indole-3-ethylamine(17726-03-3)
• EPA Substance Registry System: 1,2-dimethyl-1H-indole-3-ethylamine(17726-03-3)

Safety Data

• Hazardous Substances Data: 17726-03-3(Hazardous Substances Data)

Usage

Chemical class

Aromatic amine

Derivative of

Indole

Odor

Distinct, slightly sweet

Applications

a. Pharmaceutical production
b. Dye production
c. Fragrance production

Psychoactive effects

Potential psychoactive effects

Research and development

Applications in the research and development of new drugs targeting the central nervous system

Industrial and scientific applications

Versatile chemical with various industrial and scientific applications

InChI:InChI=1/C12H16N2/c1-9-10(7-8-13)11-5-3-4-6-12(11)14(9)2/h3-6H,7-8,13H2,1-2H3

Upstream product

• 2731-06-8 2-methyltryptamine 
• 618-40-6 1-Methyl-1-phenylhydrazine 
• 14267-92-6 1-chloro-4-pentyne 

Downstream Products

• 934478-88-3 N-(2-(1,2-dimethyl-1H-indol-3-yl)ethyl)-4-methyl-N-(prop-2-ynyl)benzenesulfonamide 

Relevant articles and documents

FUSED BICYCLIC ALKYLENE LINKED IMIDODICARBONIMIDIC DIAMIDES, METHODS FOR SYNTHESIS, AND USES IN THERARY

The present invention provides novel fused bicyclic alkylene linked imidodicarbonimidic diamides. In particular, described herein are N-[2-(indol-3- yl)alkylene]-linked imidodicarbonimidic diamides and N-[2-(pyrrolopyridin-3- yl)alkylene]-linked imidodicarbonimidic diamides (compound of formula (I) or formula (II)), and uses therefor. The compounds of the present invention are believed to be organic cation transporter selective compounds, useful for the treatment of diseases and conditions caused by reduced activity of 5' adenosine monophosphate-activated protein kinase (AMPK).

Efficient one-pot synthesis of tryptamines and tryptamine homologues by amination of chloroalkynes

A new method was developed for the one-pot synthesis of substituted 3-(2-aminoethyl)- and 3-(3-aminopropyl)indoles from commercially available aryl hydrazines and chloroalkylalkynes. Various tryptamine derivatives were prepared directly in good yield with excellent regioselectivity. The method involves a new domino reaction sequence consisting of a titanium-catalyzed amination of the chloroalkylalkyne, [3+3]-rearrangement of the resulting aryl hydrazone, and nucleophilic substitution of the chloride by ammonia.