618-40-6

Basic information

• Product Name: 1-Methyl-1-phenylhydrazine
• Synonyms: N-METHYL-N-PHENYLHYDRAZINE;1-Methyl-1-PhenylhydrazineHydrochloride;1-Methyl-1-PhenylhydrazineHcl;α-Methylphenylhydrazine, N-Methyl-N-phenylhydrazine;1-Methyl-1-phenylhydrazine,96%;1-Methyl-1-phenylhydrazine,98%;1-Methyl-1-phenylhydrazine,α-Methylphenylhydrazine, N-Methyl-N-phenylhydrazine;1-Methyl-1-phenylhydrazine, 96% 5GR
• CAS NO: 618-40-6
• Molecular Formula: C₇H₁₀N₂
• Molecular Weight: 122.17
• EINECS: 210-547-9
• Product Categories: Building Blocks;Chemical Synthesis;Hydrazines;Nitrogen Compounds;Organic Building Blocks
• Mol File: 618-40-6.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 54-55 °C0.3 mm Hg(lit.)
• Flash Point: 205 °F
• Appearance: Clear yellow to orange-brown/Liquid
• Density: 1.038 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0324mmHg at 25°C
• Refractive Index: n20/D 1.583(lit.)
• Storage Temp.: 0-6°C
• PKA: 5.37±0.10(Predicted)
• Water Solubility: Slightly soluble
• BRN: 507683
• CAS DataBase Reference: 1-Methyl-1-phenylhydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-1-phenylhydrazine(618-40-6)
• EPA Substance Registry System: 1-Methyl-1-phenylhydrazine(618-40-6)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39-45
• RIDADR: 2810
• WGK Germany: 3
• RTECS: MV7712000
• F: 8-10-23
• TSCA: Yes
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 618-40-6(Hazardous Substances Data)

Usage

Uses

1-Methyl-1-phenylhydrazine is used to make other chemicals.

InChI:InChI=1/C7H10N2/c1-9(8)7-5-3-2-4-6-7/h2-6H,8H2,1H3

Upstream product

• 614-00-6 N-methyl-N-nitrosoaniline 
• 64-19-7 acetic acid 
• 127-09-3 sodium acetate 
• 7119-93-9 N-methyl-N-nitroaniline 
• 17881-80-0 (2-picolyl)trimethylsilane 
• 2989-45-9 1-benzylidene-2-methyl-2-phenylhydrazine 
• 60-80-0 antipyrine 
• 7803-57-8 hydrazine hydrate 
• 7647-01-0 hydrogenchloride 
• 52023-39-9 N'-methyl-N'-phenylbenzohydrazide 
• 67-56-1 methanol 
• 65739-08-4 3-methyl-3-phenyl-1-(toluene-4-sulfonyl)-triazene 
• 617-35-6 2-oxo-propionic acid ethyl ester 
• 18450-24-3 ethyl N-methylindole-2-carboxylate 

Downstream Products

• 77249-37-7 2-pyridinecarboxaldehyde N-methyl-N-phenylhydrazone 
• 50670-19-4 N-methyl-N-[(E)-4-pyridylmethyleneamino]aniline 
• 38604-68-1 N'-methyl-N'-phenylacetohydrazide 
• 5905-11-3 2-(4-chlorophenyl)-1-methyl-2-phenyl-1H-indole 
• 52023-39-9 N'-methyl-N'-phenylbenzohydrazide 
• 5311-80-8 1-methyl-1-phenyl-2-propylidenehydrazine 
• 110-21-4 hydrazodicarboxamide 
• 101321-96-4 heptanal-(methyl-phenyl-hydrazone) 
• 28989-70-0 thiobenzoic acid-(N'-methyl-N'-phenyl-hydrazide) 
• 2989-45-9 1-benzylidene-2-methyl-2-phenylhydrazine 
• 69677-50-5 thiovaleric acid-(N'-methyl-N'-phenyl-hydrazide) 
• 857815-06-6 N-methyl-N'-(3-methyl-2,6-dinitro-phenyl)-N-phenyl-hydrazine 
• 857815-76-0 N-methyl-N'-(5-methyl-2,4-dinitro-phenyl)-N-phenyl-hydrazine 

Relevant articles and documents

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Rh(iii)-catalyzed, hydrazine-directed C-H functionalization with 1-alkynylcyclobutanols: A new strategy for 1: H -indazoles

Rh(iii)-catalyzed coupling of phenylhydrazines with 1-alkynylcyclobutanols was realized through a hydrazine-directed C-H functionalization pathway. This [4+1] annulation, based on the cleavage of a Csp-Csp triple bond in alkynylcyclobutanol, provides a new pathway to prepare diverse 1H-indazoles under mild reaction conditions. This journal is

An efficient synthesis of: N -nitrosamines under solvent, metal and acid free conditions using tert -butyl nitrite

Synthesis of various N-nitroso compounds from secondary amines is reported using tert-butyl nitrite (TBN) under solvent free conditions. Broad substrate scope, metal and acid free conditions, easy isolation procedure and excellent yields are few important features of this methodology. The acid labile protecting groups such as tert-butyldimethylsilyl (TBDMS) and tert-butyloxycarbonyl (Boc) as well as sensitive functional groups such as phenols, olefins and alkynes are found to be stable under the standard reaction conditions. Besides N-nitrosation, TBN is also found to be an efficient reagent in few other transformations including aryl hydrazines to aryl azides and primary amides to carboxylic acids under mild conditions.