177276-41-4

Usage

Uses

Used in Pharmaceutical Industry:
4-PIPERAZIN-1-YL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure and reactivity make it a valuable component in the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 4-PIPERAZIN-1-YL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is utilized as an intermediate in the production of agrochemicals. Its role in the synthesis of these compounds contributes to the development of effective pesticides and other agricultural chemicals that enhance crop protection and yield.

Upstream product

• 177276-39-0 1-(1,1-dimethylethoxycarbonyl)-4-[4-(phenylmethyl)-1-piperazinyl]piperidine 
• 110-85-0 piperazine 
• 141699-59-4 1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 177276-40-3 4-(1-tert-butoxycarbonylpiperidin-4-yl)piperazine-1-carboxylic acid benzyl ester 

Downstream Products

• 1010446-28-2 tert-butyl 4-{4-[2-(6-chloro-2-oxo-2,3-dihydrobenzimidazol-1-yl)-2-phenyl-acetyl]piperazin-1-yl}piperidine-1-carboxylate 
• 180532-38-1 Ethyl trans-4-[[4-[1-(tert-butyloxycarbonyl)-piperidin-4-yl]-piperazin-1-yl]-carbonyl]-cyclohexanecarboxylate 
• 1477815-41-0 4-[4-(4-bromo-3-trifluoromethoxyphenylcarbamoyl)piperazin-1-yl]piperidine-1-carboxylic acid tert-butyl ester 
• 1477815-42-1 4-{4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-trifluoromethoxyphenylcarbamoyl]piperazin-1-yl}piperidine-1-carboxylic acid tert-butyl ester 
• 1477815-33-0 4-[4-(4-bromo-2-chloro-5-trifluoromethoxyphenylcarbamoyl)piperazin-1-yl]piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Preparation method of nitrogen-containing heterocyclic derivative

The invention discloses a preparation method of a nitrogen-containing heterocyclic derivative (4-(4-bromobenyl) piperazine-1-yl) piperidine-1-tert butyl formate. The preparation method comprises the following steps: taking 4-hydroxypyrazole as a starting raw material; and carrying out Boc feeding, condensation, nucleophilic substitution and amidation to obtain an objective product. The compound isan important medical intermediate.

Preparation method of piperazine derivative

The invention discloses a preparation method of a piperazine derivative, namely (4-(4-trifluoromethyl benzoyl)piperazine-1-yl)piperidine-1-tert-butyl formate. 4-hydroxy piperazine is taken as a starting material and is subjected to Boc treatment, condensation, nucleophilic substitution and amidation to obtain a target product. The compound is an important medical intermediate.

Compound used as ALK (anaplastic lymphoma kinase) inhibitor and application thereof

The invention discloses a compound shown in a formula I, and pharmaceutically acceptable salts, stereoisomers, solvates or predrugs. The symptoms are defined in claim requirements. The compound shownin the formula I has good inhibiting activity on ALK (anaplastic lymphoma kinase), and can be used for preparing medicines for adjusting the activity of the ALK activity or treating the ALK-related diseases, especially nonsmall-cell lung cancer drugs. (The formula I is shown in the attached figure.).

Preparation method for piperazine derivative

The invention discloses a preparation method for a piperazine derivative (4-(4-methyl benzoyl) piperazine-1-yl) piperidine-1-tert-butyl formate. 4-hydroxy piperazine is taken as an initial raw material and then is subjected to Boc, condensation, nucleophilic substitution and amidation so as to acquire a target product. The compound is an important medical intermediate.

Puerarin derivative and its preparation method (by machine translation)

The invention belongs to the technical field of organic synthetic chemistry, and provides a plurality of puerarin derivatives and preparation methods thereof. The prepared puerarin derivatives have good water solubility or fat solubility, and can be quick

PIPERAZINE-PIPERIDINE COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS

The invention provides compounds of formula (I): wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of replication of the hepatitis C virus. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat hepatitis C viral infections, and processes and intermediates useful for preparing such compounds.

5-Quinoline derivatives having an anti-bacterial activity

The present invention describes novel anti-bacterial compounds of the formula (I). These compounds are, amongst others, of interest as inhibitors of DNA gyrase and topoisomerases, for example of topoisomerase II and IV.

SUBSTITUTED BENZIMIDAZOLONE DERIVATIVES, MEDICAMENTS COMPRISING THEM AND THEIR USE

The present invention relates to novel benzimidazolone derivatives of the general formula (I) in which the substituents R1, R2, R3, A1, A2, and B are as defined in claim 1, medicaments comprising these, and the use thereof for the prophylaxis and/or treatment of vasopressin-dependent diseases.

Benzenesulphonamide derivatives, method for production and use thereof for treatment of pain

The present invention concerns novel benzenesulphonamide compounds, defined by formula I and the description, their method of preparation and their use in therapy.

Compounds with platelet aggregation inhibitor activity

A compound represented by the general formula (I) and a pharmaceutically acceptable salt and solvate thereof having an effect for inhibiting the aggregation of platelets is disclosed: STR1 wherein A, B and C represent independently CH2 or C=O;