177284-93-4

Upstream product

• 32252-03-2 (-)-1'-deoxy-1'-phenyl-β-D-ribofuranose 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 177471-62-4 tert-butyl(((3aR,4R,6S,6aS)-2,2-dimethyl-6-phenyl-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)diphenylsilane 
• 14233-64-8 (3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-dihydro-furan-2-one 
• 138511-91-8 2',3',5'-tri-O-benzyl-1'-deoxy-1'-phenyl-β-D-ribofuranose 
• 108-86-1 bromobenzene 
• 174590-90-0 5-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-1-phenyl-D-ribofuranose 
• 591-51-5 phenyllithium 
• 130222-84-3 5-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribono-1,4-lactone 

Downstream Products

• 177284-94-5 5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl-1'-deoxy-1'-phenyl-β-D-ribofuranose 
• 177284-95-6 5'-O-(4,4'-dimethoxytrityl)-2'-O-tert-butyldimethylsilyl-1'-deoxy-1'-phenyl-β-D-ribofuranose 

Relevant academic research and scientific papers

C-F···H-C hydrogen bonds in ribonucleic acids

We report the synthesis of 1′-deoxy-1′-(benzimidazol-1-yl)-β-D-ribofuranose 7 and 1′-deoxy-1′-phenyl-β-D-ribofuranose 2. With these two ribonucleoside analogues we have a set of nine different RNA building blocks in hand, which are isostere to the natural

Modified Nucleosides for Ribozyme Structure-Activity Studies

C-Phenyl, C-p-aminophenyl and C-naphthyl as well as pyridine-4(2)-one ribofuranosides were synthesized and site-specifically incorporated into a hammerhead ribozyme using solid phase synthesis.The modified oligonucleotides were used to probe the structural requirements at position 7 for catalytic activity.A pyridine-4-one-base substitution at a single position (N7) within the ribozyme catalytic core increased catalytic rate 10-fold.C-Phenyl, N3-methyluracyl, and p-aminophenyl base substitution at N7 reproducibly increased the catalytic rate twofold.