177338-13-5

Basic information

• Product Name: Silane, (3-bromopropoxy)(1,1-dimethylethyl)diphenyl-
• CAS NO: 177338-13-5
• Molecular Formula: C19H25BrOSi
• Molecular Weight: 377.396
• Mol File: 177338-13-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Silane, (3-bromopropoxy)(1,1-dimethylethyl)diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, (3-bromopropoxy)(1,1-dimethylethyl)diphenyl-(177338-13-5)
• EPA Substance Registry System: Silane, (3-bromopropoxy)(1,1-dimethylethyl)diphenyl-(177338-13-5)

Safety Data

• Hazardous Substances Data: 177338-13-5(Hazardous Substances Data)

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 627-18-9 1-bromo-3-propanol 

Downstream Products

• 203449-34-7 5-t-butyldiphenylsilanyloxy-2,2-dimethylpentanal 
• 777075-10-2 4-methyl-trans-4-hexenol tert-butyldiphenylsilyl ether 
• 1020296-64-3 C₂₁H₂₈O₂SSi 
• 1248623-36-0 2-[4-(N-monomethylamino)phenyl]-6-[3-(t-butyldiphenylsilyloxy)propoxy]benzothiophene 
• 221132-37-2 2-(3-tert-butyldiphenylsiloxy-propyl)-hex-5-enoic acid methyl ester 
• 221132-22-5 [2-(3-tert-butyldiphenylsiloxy-propyl)-1,1-divinyl-hex-5-enyloxymethyl]-4-methoxy-benzene 
• 221132-20-3 4-(3-tert-butyldiphenylsiloxy-propyl)-3-vinyl-hepta-1,6-dien-3-ol 
• 382139-44-8 4,4-dimethyl-7-t-butyldiphenylsilanyloxy-1-heptene-3-ol 

Relevant articles and documents

TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR

Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula (I) and Formula (II) have the following structures: (I); (II). Intermediates (V) are also claimed.

BICYCLIC-PYRIMIDINEDIONE COMPOUNDS

The present invention provides novel bicyclic pyrimidinedione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.

Asymmetric Synthesis of Spiroketals with Aminothiourea Catalysts

Chiral spiroketal skeletons are found as core structures in a range of bioactive compounds. These natural compounds and their analogues have attracted much attention in the field of drug discovery. However, methods for their enantioselective construction are limited, and easily available optically active spiroketals are rare. We demonstrate a novel catalytic asymmetric synthesis of spiroketal compounds that proceeds through an intramolecular hemiacetalization/oxy-Michael addition cascade mediated by a bifunctional aminothiourea catalyst. This results in spiroketal structures through the relay formation of contiguous oxacycles, in which multipoint recognition by the catalyst through hydrogen bonding imparts high enantioselectivity. This method offers facile access to spiroketal frameworks bearing an alkyl group at the 2-position, which are prevalent in insect pheromones. Optically active (2S,5S)-chalcogran, a pheromone of the six-spined spruce bark beetle, and an azide derivative could be readily synthesized from the bicyclic reaction product. Around and around: A catalytic asymmetric synthesis of spiroketals through an intramolecular hemiacetalization/oxy-Michael addition cascade with a bifunctional aminothiourea catalyst was developed. This method offers facile access to spiroketal frameworks bearing an alkyl group at the 2-position. Optically active (2S,5S)-chalcogran, a pheromone from the six-spined spruce bark beetle, and a derivative were readily synthesized from the bicyclic reaction product.