17734-25-7

Upstream product

• 78573-85-0 1-bromo-7-phenyl-heptane 
• 151-50-8 potassium cyanide 
• 26447-64-3 1-phenyl-3-heptene 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 3208-25-1 7-phenylheptan-1-ol 
• 58654-08-3 7-iodoheptanenitrile 
• 100-39-0 benzyl bromide 

Downstream Products

• 128648-98-6 8-Phenyl-octanamidine 
• 17734-23-5 8--phenyloctan--1--amine 

Relevant academic research and scientific papers

Nickel-Catalyzed Migratory Hydrocyanation of Internal Alkenes: Unexpected Diastereomeric-Ligand-Controlled Regiodivergence

A regiodivergent nickel-catalyzed hydrocyanation of a broad range of internal alkenes involving a chain-walking process is reported. When appropriate diastereomeric biaryl diphosphite ligands are applied, the same starting materials can be converted to either linear or branched nitriles with good yields and high regioselectivities. DFT calculations suggested that the catalyst architecture determines the regioselectivity by modulating electronic and steric interactions. In addition, moderate enantioselectivities were observed when branched nitriles were produced.

2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia

This invention provides compounds of Formula I having the structure wherein:B, C, D, and R1 are as defined hereinbefore in the specification, or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.

Cross-Coupling between Functionalized Alkylcopper Reagents and Functionalyzed Alkyl Halides

Functionalized dialkylzincs treated with Me2Cu(CN)(MgCl)2 in DMPU undergo highly chemoselective cross-coupling reactions with functionalized alkyl iodides or benzylic bromides providing polyfunctional products in good to excellent yields.