177366-73-3Relevant academic research and scientific papers
Reactions of 1-acylamino-1-(trimethylsiloxy)alkanes: Versatile precursors to acylimines
Johnson, A. Peter,Luke, Richard W. A.,Boa, Andrew N.
, p. 895 - 905 (2007/10/03)
1-Acylamino-1-(trimethylsiloxy)alkanes react with carbon and heteroatom nucleophiles to give the corresponding 1-substituted-1-acylaminoalkanes. The 1-acylamino-1-(trimethylsiloxy)alkanes can also give rise to enamides, and by this route the mild antibiotic tuberin, and the isomeric (Z)-tuberin have been prepared. A further example of their reactions is illustrated with the acid-catalysed intramolecular cyclisation onto a carbon-carbon double bond. These transformations show that 1-acylamino-1-(trimethylsiloxy)alkanes are versatile precursors to synthetically useful acylimines.
A Novel Trimerization of 1-Phenylsulfanyl-2,2,2-trifluoroethyl Isocyanide Giving a Dihydropyrimidine Derivative
Uno, Hidemitsu,Oka, Kenji,Tani, Hiroyuki,Kawada, Yoshihiro,Ono, Noboru
, p. 1763 - 1767 (2007/10/03)
1-Phenylsulfanyl-2,2,2-trifluoroethyl isocyanide (2a) readily and selectively trimerized to 4,6-bis(phenylsulfanyl)-1-(1-phenylsulfanyl-2,2,2-trifluoroethyl)-5-(2,2,2- trifluoroethylideneamino)-2-trifluoromethyl-1,2-dihydropyrimidine (5) at room temperature, while other α-phenylsulfanyl isocyanides such as phenyl(phenylsulfanyl)methyl isocyanide (2b) are stable. Heating of 2b resulted in formation of the corresponding nitrile as well as diphenyl disulfide and [bis(phenylsulfanyl)methyl]benzene.
