17738-71-5

Basic information

• Product Name: (4-CHLOROPHENYL)AMINO](OXO)ACETIC ACID
• Synonyms: Aceticacid, [(4-chlorophenyl)amino]oxo- (9CI); Oxanilic acid, 4'-chloro- (8CI);4'-Chlorooxanilic acid; N-(4-Chlorophenyl)oxamic acid; p-Chlorooxanilic acid
• CAS NO: 17738-71-5
• Molecular Formula: C₈H₆ClNO₃
• Molecular Weight: 199.59114
• Mol File: 17738-71-5.mol
• Article Data: 15

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.546g/cm³
• CAS DataBase Reference: (4-CHLOROPHENYL)AMINO](OXO)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (4-CHLOROPHENYL)AMINO](OXO)ACETIC ACID(17738-71-5)
• EPA Substance Registry System: (4-CHLOROPHENYL)AMINO](OXO)ACETIC ACID(17738-71-5)

Safety Data

• Hazardous Substances Data: 17738-71-5(Hazardous Substances Data)

Usage

General Description

"(4-Chlorophenyl)amino](oxo)acetic acid, also known as N-Chloroacetyl-4-aminobenzoic acid or N-chloroacetyl-p-aminobenzoic acid, is a chemical compound with the molecular formula C8H7ClNO3. It is a derivative of p-aminobenzoic acid with an additional acetyl group and a chlorine atom attached to the amino group. (4-CHLOROPHENYL)AMINO](OXO)ACETIC ACID has been synthesized for potential use as a pharmaceutical intermediate or in the production of dyes and pigments. It is a white to off-white crystalline powder and is a known irritant to the skin, eyes, and respiratory system. "(4-Chlorophenyl)amino](oxo)acetic acid is also a suspected environmental toxin and may have harmful effects on aquatic life if released into water systems."

InChI:InChI=1/C8H6ClNO3/c9-5-1-3-6(4-2-5)10-7(11)8(12)13/h1-4H,(H,10,11)(H,12,13)/p-1

Upstream product

• 17722-17-7 N-(4-chlorophenyl)-2-cyanoacetamide 
• 41374-66-7 methyl 2-[(4-chlorophenyl)amino]-2-oxoacetate 
• 106-47-8 4-chloro-aniline 
• 5397-14-8 ethyl 2-[(4-chlorophenyl)amino]-2-oxoacetate 
• 4755-77-5 Ethyl oxalyl chloride 
• 17118-74-0 ethyl oxalylchloride 

Downstream Products

• 104-12-1 p-chlorphenylisocyanate 
• 1040763-02-7 C₂₁H₁₁BrCl₂F₃N₃O₃ 
• 1253393-98-4 C₁₄H₁₈ClN₃O₂ 
• 1211293-87-6 C₂₀H₂₂ClN₃O₂ 
• 20406-14-8 4-Chlor-oxanilsaeurechlorid 
• 331264-58-5 C₁₄H₁₇ClN₂O₂ 
• 13208-64-5 1-(4-chlorophenyl)-3-propylurea 
• 13208-51-0 3-(4-chlorophenyl)-1-(phenylmethyl)urea 
• 13142-10-4 1-(4-bromophenyl)-3-(4-chlorophenyl)urea 

Relevant articles and documents

Exploratory studies on soluble small molecule CD4 mimics as HIV entry inhibitors

Several small molecule CD4 mimics, which inhibit the interaction of gp120 with CD4, have been developed. Original CD4 mimics such as NBD-556, which has an aromatic ring, an oxalamide linker and a piperidine moiety, possess significant anti-HIV activity bu

Direct C3 Carbamoylation of 2H-Indazoles

We developed a novel method for direct C3 carbamoylation of 2H-indazoles using oxamic acids as carbamoyl radical sources. In the presence of ammonium persulfate, carbamoyl radicals were generated from oxamic acids, then used for further reactions with 2H-indazoles to afford the desired products. The reaction proceeds under metal- and catalyst-free conditions. This simple process allows for the efficient synthesis of C3 carbamoylated 2H-indazoles, which are important scaffolds in organic synthesis.

POLYCYCLIC COMPOUND ACTING AS IDO INHIBITOR AND/OR IDO-HDAC DUAL INHIBITOR

The present invention provides polycyclic compounds as IDO inhibitors and/or dual inhibitors of IDO-HDAC. Specifically, the present invention provides compounds represented by the following formula (I), wherein each group is defined as described in the specification. The compounds have IDO inhibitory activity or IDO-HDAC dual inhibitory activity and can be used for preventing or treating diseases associated with IDO and/or IDO-HDAC activity or expression levels. At the same time, the compounds of the present invention can be combined with an antitumor antibody such as PD-1 and PD-L1, and such a combination can greatly increase the antitumor response rate of the antibody and broaden the types of tumors to be treated.