177415-48-4Relevant academic research and scientific papers
(2R,3S,5S)-2-Acetoxy-3-fluoro-5-(p-toluoyloxymethyl)tetrahydrofuran: A key intermediate for the practical synthesis of 9-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine (FddA)
Jin, Fuqiang,Wang, Dengjin,Confalone, Pat N.,Pierce, Michael E.,Wang, Zhe,Xu, Guoyou,Choudhury, Anusuya,Nguyen, Dieu
, p. 4787 - 4789 (2007/10/03)
A highly efficient synthesis of (2R,3S,5S)-2-acetoxy-3-fluoro-5-(p-toluoyloxymethyl)tetrahydrofuran (2a) was developed. As a key intermediate, 2a was effectively applied to the synthesis of 9-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine (FddA), thus, providing a practical synthetic approach to FddA.
