363625-99-4

Basic information

• Product Name: (3R,5S)-3-fluoro-5-(p-toluoyloxymethyl)-2-tetrahydrofuranone
• Synonyms: (3R,5S)-3-fluoro-5-(p-toluoyloxymethyl)-2-tetrahydrofuranone
• CAS NO: 363625-99-4
• Molecular Weight: 252.242
• Mol File: 363625-99-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R,5S)-3-fluoro-5-(p-toluoyloxymethyl)-2-tetrahydrofuranone(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,5S)-3-fluoro-5-(p-toluoyloxymethyl)-2-tetrahydrofuranone(363625-99-4)
• EPA Substance Registry System: (3R,5S)-3-fluoro-5-(p-toluoyloxymethyl)-2-tetrahydrofuranone(363625-99-4)

Safety Data

• Hazardous Substances Data: 363625-99-4(Hazardous Substances Data)

Upstream product

• 154540-16-6 (S)-(-)-2-Fluoro-4-(hydroxymethyl)-2-buten-4-olide 
• 363625-98-3 4-Methyl-benzoic acid (S)-4-fluoro-5-oxo-2,5-dihydro-furan-2-ylmethyl ester 

Downstream Products

• 363625-97-2 (3R,5S,5S)-2-acetoxy-3-fluoro-5-(p-toluoyloxymethyl)tetrahydrofuran 
• 166411-50-3 9-(2,3-dideoxy-2-fluoro-α-D-threo-pentofuranosyl)adenine 
• 177415-48-4 4-Methyl-benzoic acid (2S,4S,5R)-5-bromo-4-fluoro-tetrahydro-furan-2-ylmethyl ester 
• 110143-10-7 iodenosine 

Relevant articles and documents

(2R,3S,5S)-2-Acetoxy-3-fluoro-5-(p-toluoyloxymethyl)tetrahydrofuran: A key intermediate for the practical synthesis of 9-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine (FddA)

A highly efficient synthesis of (2R,3S,5S)-2-acetoxy-3-fluoro-5-(p-toluoyloxymethyl)tetrahydrofuran (2a) was developed. As a key intermediate, 2a was effectively applied to the synthesis of 9-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine (FddA), thus, providing a practical synthetic approach to FddA.