177429-30-0

Upstream product

• 6702-50-7 3-hydroxy-4-methoxybenzoate 
• 563-47-3 3-Chloro-2-methylpropene 
• 645-08-9 Isovanillic acid 

Downstream Products

• 913985-08-7 4-methoxy-3-((2-methylallyl)oxy)benzoic acid 
• 913985-16-7 4-methoxy-3-[(5-methyl-3-phenyl-4,5-dihydro-isoxazol-5-yl)methoxy]-benzoic acid methyl ester 
• 913985-18-9 4-methoxy-3-[(5-methyl-3-p-tolyl-4,5-dihydro-isoxazol-5-yl)-methoxy]-benzoic acid methyl ester 
• 913985-20-3 4-methoxy-3-[(5-methyl-3-pyridin-3-yl-4,5-dihydro-isoxazol-5-yl)methoxy]benzoic acid methyl ester 
• 913985-22-5 4-butoxy-3-[(5-methyl-3-pyridin-3-yl-4,5-dihydro-isoxazol-5-yl)methoxy]benzoic acid methyl ester 
• 913985-09-8 N-(3,5-dichloro-pyridin-4-yl)-4-methoxy-3-(2-methyl-allyloxy)-benzamide 
• 913985-19-0 4-methoxy-3-[(5-methyl-3-p-tolyl-4,5-dihydro-isoxazol-5-yl)-methoxy]-benzoic acid 
• 913985-21-4 4-hydroxy-3-[(5-methyl-3-pyridin-3-yl-4,5-dihydro-isoxazol-5-yl)methoxy]benzoic acid methyl ester 
• 913985-17-8 4-methoxy-3-[(5-methyl-3-phenyl-4,5-dihydro-isoxazol-5-yl)methoxy]-benzoic acid 

Relevant academic research and scientific papers

Ruthenium-Catalyzed Hydroarylation and One-Pot Twofold Unsymmetrical C?H Functionalization of Arenes

A methyl phenyl sulfoximine (MPS) is used as a directing group in the ruthenium-catalyzed intramolecular hydroarylation of alkene-tethered benzoic acid derivatives to afford dihydrobenzofurans and indolines in good to excellent yields. A one-pot, unsymmetrical, twofold C?H functionalization involving intramolecular C?C and intermolecular C?C/C?N bond formations is successfully demonstrated by using a single set of catalytic reaction conditions, which is unprecedented thus far. A novel isoquinolone-bearing dihydrobenzofuran is constructed through an unsymmetrical twofold C?H functionalization.

Sulfoximine-Assisted One-Pot Unsymmetrical Multiple Annulation of Arenes: A Combined Experimental and Computational Study

Discussed herein is an unprecedented Ru-catalyzed one-pot unsymmetrical C-H difunctionalization of arenes comprising intramolecular hydroarylation of olefins and intermolecular annulation of alkynes. This unprecedented 2-fold C-H functionalization is validated on the basis of experimental and density functional theory (DFT) study. The transformation readily occurs with the assistance of methylphenyl sulfoximine (MPS) directing group in the presence of Ru catalyst forming two C-C and one C-N bonds in a single operation. The overall process is atom economical and step-efficient and provides unusual dihydrofuran-fused isoquinolone heterocycles. Further annulation of NH and the proximal o-C-H-arene of isoquinolone with alkynes build highly conjugated novel polycyclic compounds. Overall, three independent annulations in arene motifs are visualized and thoughtfully executed; finally, 5 ring-fused structural entities are constructed forming three C-C and two C-N bonds.

AZOLE-BASED PHOSPHODIESTERASE INHIBITORS

The present invention relates to phosphodiesterase (PDE) type IV selective inhibitors. Processes for the preparation of disclosed compounds of Formula (I), pharmaceutical compositions containing the compounds described herein and their use as PDE type IV selective inhibitors are provided.

Dihydrobenzofurane

PCT No. PCT/EP95/02841 Sec. 371 Date Apr. 15, 1997 Sec. 102(e) Date Apr. 15, 1997 PCT Filed Jul. 19, 1995 PCT Pub. No. WO96/03399 PCT Pub. Date Feb. 8, 1996The invention concerns componuds of formula (I), in which R1, R2, R3 and R4 have the meanings given in the description. The compounds are novel, effective PDE-inhibitors.