17745-77-6Relevant academic research and scientific papers
Direct amination of olefins through sequential triazolinedione ene reaction and carbanion-assisted cleavage of the N-N urazole bond
Adam, Waldemar,Pastor, Aurelia,Wirth, Thomas
, p. 1295 - 1297 (2007/10/03)
(formula presented) Allylic amines 5 are obtained in 30-55% overall yields by the base-catalyzed hydrolysis of trialkylated allylic urazoles 3; the latter are prepared by the TAD ene reaction of the appropriate olefin and further N-alkylation with α-bromo
Microbial reduction of N-allylhydroxylamines to N-allylamines using clostridia
Braun,Schmidtchen,Schneider,Simon
, p. 3329 - 3334 (2007/10/02)
Chiral organic hydroxylamines can be reduced to the corresponding chiral amines in high yield without racemization using resting cells of C. kluyveri, C. tyrobutyricum or C. thermoaceticum in aqueous buffer with H2, CO or Na-formate as reducing agents. These reduction systems are unselective with respect to substrate chirality and leave C-C double bonds and aliphatic carbon-chlorine bonds unharmed. Considering the product inhibition by the amines optimized reaction conditions were elaborated to employ formate, and 60-120 mg wet packed cells of C. thermoaceticum for reducing 0.1 mmol substrate in 1 hour.
