177490-97-0

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 177490-90-3 5'-(S)-C-(azidomethyl)-3'-O-(tert-butyldimethylsilyl)thymidine 
• 142325-10-8 5′-deoxy-5′-C-methenyl-3′-O-(tert-butyldimethylsilyl)thymidine 
• 177491-15-5 1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(S)-oxiranyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

5'-C-Branched thymidines: Synthesis, stereochemistry, and incorporation into oligodeoxynucleotides

Thymidine was converted to its 5'(S)-epoxy derivative, which reacted with nucleophiles to give 5'(S)-C-aminomethyl-, 5'(S)-C-azidomethyl, 5'(S)-C-cyanomethyl-, and 5'(S)-C-methoxymethyl-thymidine with defined stereochemistry. 5'-C-Allyl- and 5'-C-nitromethylthymidines were prepared from an aldehyde derivative. Stereochemistry of 5'-C-branched thymidines was assigned with the help of NOE experiments. Four 5'-C-branched thymidines were incorporated into oligodeoxynucleotides.