1775-23-1

Usage

Diazo compound

A compound containing a diazo group (-N2) 2,3-Dihydro-2-diazo-1H-indene-1-one is a diazo compound because it has a diazo group in its molecular structure.

Physical appearance

Orange-red solid 2,3-Dihydro-2-diazo-1H-indene-1-one appears as an orange-red solid when in its pure form.

Light-sensitive

The compound reacts when exposed to light 2,3-Dihydro-2-diazo-1H-indene-1-one can undergo decomposition or transformation when exposed to light, making it important to store and handle it away from light sources.

Potentially explosive

It can explode under certain conditions Due to its chemical nature, 2,3-Dihydro-2-diazo-1H-indene-1-one can be explosive when subjected to heat, impact, or friction, so it requires careful handling and storage.

Diazo transfer reagent

Capable of transferring a diazo group to other compounds 2,3-Dihydro-2-diazo-1H-indene-1-one is used in organic synthesis to transfer a diazo group to other molecules, such as alkenes and alkynes, resulting in the formation of new diazo compounds.

Applications in chemistry

Synthesis of complex organic molecules and pharmaceuticals 2,3-Dihydro-2-diazo-1H-indene-1-one is used in the field of chemistry to create complex organic molecules and pharmaceuticals, taking advantage of its diazo transfer capabilities.

InChI:InChI=1/C9H7N2O/c10-11-8-5-6-3-1-2-4-7(6)9(8)12/h1-4,10H,5H2/q+1

Upstream product

• 15028-10-1 indan-1,2-dione-2-oxime 
• 101351-16-0 toluene-4-sulfonic acid-(1-oxo-indan-2-ylidenehydrazide) 
• 33279-07-1 2-hydroxymethylidene-1-indanone 
• 83-33-0 inden-1-one 
• 56794-24-2 2,3-dihydro-1-oxo-1H-indene-2-carbaldehyde 

Downstream Products

• 163222-89-7 1,2-dihydrocyclobutabenzene-1-carboxylic acid 
• 61599-85-7 bicyclo[4.2.0]octa-1,3,5-trien-7-amine 
• 114425-10-4 (1,2-dihydro-cyclobutabenzen-1-yl)-diphenyl-methanol 

Relevant academic research and scientific papers

Evolution of a Strategy for the Enantioselective Total Synthesis of (+)-Psiguadial B

(+)-Psiguadial B is a diformyl phloroglucinol meroterpenoid that exhibits antiproliferative activity against the HepG2 human hepatoma cancer cell line. This full account details the evolution of a strategy that culminated in the first enantioselective total synthesis of (+)-psiguadial B. A key feature of the synthesis is the construction of the trans-cyclobutane motif by a Wolff rearrangement with in situ catalytic, asymmetric trapping of the ketene. An investigation of the substrate scope of this method to prepare enantioenriched 8-aminoquinolinamides is disclosed. Three routes toward (+)-psiguadial B were evaluated that featured the following key steps: (1) an ortho-quinone methide hetero-Diels-Alder cycloaddition to prepare the chroman framework, (2) a Prins cyclization to form the bridging bicyclo[4.3.1]decane system, and (3) a modified Norrish-Yang cyclization to generate the chroman. Ultimately, the successful strategy employed a ring-closing metathesis to form the seven-membered ring and an intramolecular O-arylation reaction to complete the polycyclic framework of the natural product.

Synthesis of pyrazoles through catalyst-free cycloaddition of diazo compounds to alkynes

The synthesis of pyrazoles via 1,3-dipolar cycloaddition of diazo compounds to alkynes proceeds easily by heating. With α-diazocarbonyl substrates the reactions are conducted under solvent-free conditions affording the pyrazole products in high yields wit

A Simple Procedure for Preparation of α-Diazocarbonyl Compounds

The use of 1,8-diazabicycloundec-7-ene as a base in Regitz reaction leads to improved yields of α-diazocarbonyl compounds in much shorter time (15 min).