177547-63-6

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 78739-32-9 1-O-Benzoyl-D-erythro-C₁₈-sphingosine hydrochloride 
• 173531-24-3 (4S,1'S,2'R)-4-(1',2'-Epoxybut-3'-enyl)-2-phenyl-4,5-dihydrooxazole 
• 173531-22-1 Methanesulfonic acid (1R,2S,3R)-2,4-dihydroxy-3-methanesulfonyloxy-1-((S)-2-phenyl-4,5-dihydro-oxazol-4-yl)-butyl ester 
• 173531-23-2 (1'R,2'R,4S)-1'-Methylsulfonyloxy-1'-(2-phenyl-4,5-dihydrooxazol-4-yl)but-3'-en-2'-ol 
• 78715-85-2 erythro-4-(1-hydroxy-2-hexadecenyl)-2-phenyl-Δ²-oxazoline 
• 15890-72-9 laurylmagnesium bromide 

Downstream Products

• 123-78-4 (2S,3R,4E)-2-amino-4-octadecene-1,3-diol 

Relevant academic research and scientific papers

Efficient stereocontrolled synthesis of D-erythro-sphingosine from N-benzoyl-D-glucosamine

D-erythro-Sphingosine is synthesized from N-benzoyl-D-glucosamine 2 in a highly regio- and stereo-controlled manner. The key features in the synthesis involve the efficient conversion of compound 2 into the vinyl epoxide 10 and the subsequent SN2′-type reaction with a Grignard reagent in the presence of CuCN to afford the 1-O,2-N-protected sphingosine 11.