17755-10-1

Usage

Uses

Used in Chemical Reactions and Organic Synthesis:
[1,1-Biphenyl]-2-ol,3-methyl-(9CI) is used as a reactant in various chemical reactions and organic synthesis processes. Its unique structure allows it to participate in a range of reactions, contributing to the formation of diverse chemical products.
Used in Chemical Production as a Building Block:
In the chemical industry, [1,1-Biphenyl]-2-ol,3-methyl-(9CI) is used as a building block for the production of other chemicals. Its molecular structure provides a foundation for creating more complex compounds, enhancing the versatility of chemical manufacturing processes.
Potential Use in Pharmaceutical and Biological Research:
While further research is required, [1,1-Biphenyl]-2-ol,3-methyl-(9CI) may exhibit certain biological activities or properties that could be valuable in pharmaceutical and biological research. Its potential applications in these fields could include the development of new drugs or the study of biological processes.

InChI:InChI=1/C13H12O/c1-10-6-5-9-12(13(10)14)11-7-3-2-4-8-11/h2-9,14H,1H3

Upstream product

• 100-34-5 benzene diazonium chloride 
• 95-48-7 ortho-cresol 
• 7320-53-8 4-methyl-dibenzofuran 
• 14562-10-8 2-hydroxy-3-phenylbenzaldehyde 
• 108-86-1 bromobenzene 
• 87-64-9 2-chloro-6-methylphenol 
• 98-80-6 phenylboronic acid 
• 1100054-83-8 6-methylene-2-phenyl-2-cyclohexen-1-one 
• 72569-05-2 ortho-methylphenyl pivalate 
• 66003-76-7 Diphenyliodonium triflate 
• 201230-82-2 carbon monoxide 
• 144930-50-7 mesityl(phenyl)iodonium triflouromethanesulfonate 
• 591-50-4 iodobenzene 
• 4783-78-2 2-(o-tolyloxy)pyridine 

Downstream Products

• 21389-91-3 2-<2-Methyl-6-phenylphenoxy>-aethyl-diaethylamin 
• 1258268-39-1 C₁₆H₁₁Cl₂N₃O 
• 22040-08-0 O-3-benzylbiphenyl-2-ol 
• 22040-03-5 2-Methyl-6-phenyl-phenylether 
• 17361-99-8 4-bromo-6-methyl-2-phenylphenol 

Relevant academic research and scientific papers

Copper-catalyzed meta-selective arylation of phenol derivatives: An easy access to m-aryl phenols

Achieving selective meta-functionalization of phenols is a significant challenge. Accessing such compounds generally needs elevated temperature or incorporation of complex templates. Here, we report a general approach to achieve meta-arylated phenols with a simple and common directing group. This coppercatalyzed protocol proceeds with complete meta-selectivity and tolerates a variety of functional groups in both coupling partners. Computational studies have revealed that the reaction proceeded via a Heck-like pathway.

Palladium-Catalyzed Reductive [5+1] Cycloaddition of 3-Acetoxy-1,4-enynes with CO: Access to Phenols Enabled by Hydrosilanes

A new palladium-catalyzed reductive [5+1] cycloaddition of 3-acetoxy-1,4-enynes with CO, enabled by hydrosilanes, has been developed for delivering valuable functionalized phenols. This methodology employs hydrosilanes as the external reagent to facilitate the [5+1] carbonylative benzannulation. The reaction is a conceptually and mechanistically novel carbonylative cycloaddition route for the construction of substituted phenols, through the formation of four new chemical bonds, with excellent functional-group tolerance.

P(NMe2)3-promoted ortho-selective arylation of phenols with diaryliodonium triflates via rhodium catalysis

Rh-catalyzed ortho-selective arylation of free phenol with diaryliodonium triflates to widely existed phenol-containing biaryls have been developed. The use of P(NMe2)3, tBuOLi and CH3CN proved to be critical for the ortho-selectivity of this reaction.

Stoichiometric to catalytic reactivity of the aryl cycloaurated species with arylboronic acids: Insight into the mechanism of gold-catalyzed oxidative C(sp2)-H arylation

Based on the well-defined five-membered aryl gold(iii) complexes, [Au(tpy)X2] (3a and 3b) and [AuBr(Ph)(tpy)] (7), as well as the aryl gold(iii) complex [AuCl2(Ph)(tpy)] (8) (tpy = 2-(o-tolyl)pyridine) as reliable models, we present a detailed study of the mechanism for gold(iii)-catalyzed oxidative cross-coupling reactions between cycloaurable arenes and arylboronic acids. Here we report the direct evidence for a mechanistic proposal including arene C-H activation, transmetallation and biaryl reductive elimination. The chelation-assisted C-H activation strategy has been used for the development of the gold(iii)-catalyzed C-H bond arylation of arenes with aryl reagents to forge extended π-conjugated systems. This journal is

P-directed borylation of phenols

Internal borylation occurs upon activation of aryl di-isopropylphosphinite boranes with HNTf2 to give heterocyclic intermediates that can be reductively quenched to afford 6 or treated with KHF2 to give the phenolic potassium aryl trifluoroborate salts 10. The latter salts are useful for Pd-catalyzed coupling with aryl iodides under Molander conditions, provided that precautions are taken to remove the KNTf2 byproduct from the preceding KHF2 step.

HYDROCARBON RECOVERY FROM SULFONES FORMED BY OXIDATIVE DESULFURIZATION PROCESS

The process provided herein is concerned with recovery of hydrocarbons from sulfones using an individual alkali and alkaline-earthy base and a mixture of thereof. As the starting materials are sulfones generated by ODS and commercially inexpensive alkali and alkaline-earth bases, the cost and ecological impact of solid waste disposal is minimized.

Synthesis of substituted phenols by using the ring-closing metathesis/isoaromatization approach

Ring-closing olefin metathesis (RCM) of 4-methylene-1,7-octadien-3-ones 2, followed by isomerization of the carbon-carbon double bond of 6-methylene-2-cyclohexenones 3 from exo to endo, produced various phenols 4. As an application of the method, the RCM/

Ruthenium-catalyzed rearrangement of cis-1-ethynyl-2-vinyloxiranes to substituted phenols

Catalytic cyclization of cis-1-ethynyl-2-vinyloxiranes was implemented with TpRuPPh3(CH3CN)2PF6 catalyst (10 mol%), to give 2,6-disubstituted phenols in reasonable yields. Under similar conditions, 1,1,2,2-tetrasubstituted oxirane gave the 2,3,6-trisubstituted phenol with skeleton reorganization. On the basis of 2H- and l3C-labeling results, we propose that the reaction mechanism involves electrocyclization of ruthenium-vinylidene intermediate with cleavage of the carbon-oxygen bond of the epoxide. Georg Thieme Verlag Stuttgart.

Suzuki-Miyaura cross-coupling reaction catalyzed by Pd/MgLa mixed oxide

A new, reusable Pd/MgLa mixed oxide catalyst has been applied successfully in the Suzuki-Miyaura carbon-carbon cross-coupling reaction of aryl halides as well as benzylic bromide with boronic acids in ethanol. The catalyst is air stable, can be stored and handled under an ambient atmosphere and after the reaction it can be recovered by simple filtration and reused without significant loss of activity. The Royal Society of Chemistry 2005.

Efficient synthesis of substituted biaryl anilines and biaryl phenols via a Suzuki cross-coupling reaction

An efficient synthesis of biaryl building blocks with multiple point diversities via a Suzuki cross-coupling reaction using a commercially available preformed Pd catalyst 1 was reported. Substituted biaryl anilines and phenols were obtained in one step from commercially available aryl halides.