177564-18-0Relevant academic research and scientific papers
1,4-DIARYL-2-AZETIDINONES WITH ANTI-TUMORAL ACTIVITY
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Page/Page column 9, (2013/03/26)
Disclosed are compounds of formula (I): wherein one of A and B is the group:(II) wherein R1 is selected from H and OCH3, and the other is the group:(III) wherein R2 is selected from H, OH, NO2, NH2; R
Synthesis and biological evaluation of 1,4-diaryl-2-azetidinones as specific anticancer agents: Activation of adenosine monophosphate activated protein kinase and induction of apoptosis
Tripodi, Farida,Pagliarin, Roberto,Fumagalli, Gabriele,Bigi, Alessandra,Fusi, Paola,Orsini, Fulvia,Frattini, Milo,Coccetti, Paola
experimental part, p. 2112 - 2124 (2012/05/21)
A series of novel 1,4-diaryl-2-azetidinones were synthesized and evaluated for antiproliferative activity, cell cycle effects, and apoptosis induction. Strong cytotoxicity was observed with the best compounds (±)-trans-20, (±)-trans-21, and enantiomers (+
Lead identification of conformationally restricted β-lactam type combretastatin analogues: Synthesis, antiproliferative activity and tubulin targeting effects
Carr, Miriam,Greene, Lisa M.,Knox, Andrew J.S.,Lloyd, David G.,Zisterer, Daniela M.,Meegan, Mary J.
scheme or table, p. 5752 - 5766 (2011/02/23)
The synthesis and study of the structure-activity relationships of a series of rigid analogues of combretastatin A-4 are described which contain the 1,4-diaryl-2-azetidinone (β-lactam) ring system in place of the usual ethylene bridge present in the natur
