177587-71-2Relevant academic research and scientific papers
Optically active substituted phenylalkylamine derivatives
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, (2008/06/13)
The present invention relates to an optically active, substituted phenylalkylamine derivative represented by Formula [1]: STR1 wherein A is a substituted or non-substituted phenyl or thienyl; X1 is hydrogen, halogen, hydroxyl or a substituted o
Synthesis and SAR of 1-alkyl-2-phenylethylamine derivatives designed from N,N-dipropyl-4-methoxy-3-(2-phenylethoxy)phenylethylamine to discover σ1 ligands
Nakazato, Atsuro,Kumagai, Toshihito,Ohta, Kohmei,Chaki, Shigeyuki,Okuyama, Shigeru,Tomisawa, Kazuyuki
, p. 3965 - 3970 (2007/10/03)
The synthesis and structure-activity relationships (SAR) of 1-alkyl-2- phenylethylamine derivatives 5-8 designed from N,N-dipropyl-2-[4-methoxy-3- (2-phenylethoxy)phenyl]ethylamine hydrochloride (1, NE-100) are presented. The SAR between compound 1 and 1-alkyl-2-phenylethylamine derivatives suggested that the alkyl group on the 1-position carbon of 2-[4-methoxy-3-(2- phenylethyl)phenyl]ethylamine derivatives played the role of one of the propyl groups on the aminic nitrogen of compound 1. (-)-N-Propyl-1-butyl-2- [4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine hydrochloride ((-)-6d, NE-537) and (-)-N-propyl-1-(3-methybutyl)-2-[4-methoxy-3-(2- phenylethoxy)phenyl]ethylamine hydrochloride ((-)-6i, NE-535), typical compounds in this series, have potent and selective σ1 affinity.
