1776-18-7Relevant academic research and scientific papers
Synthesis and Evaluation of Galloyl Conjugates of Flavanones as BMP-2 Upregulators with Promising Bone Anabolic and Fracture Healing Properties
Raj Pandey, Alka,Rai, Divya,Singh, Suriya Pratap,Tripathi, Ashish Kumar,Sardar, Anirban,Ansari, Alisha,Mishra, Anjali,Bhagwati, Sudha,Bhatta, Rabi Sankar,Siddiqi, Mohammad Imran,Chattopadhyay, Naibedya,Trivedi, Ritu,Sashidhara, Koneni V.
, p. 12487 - 12505 (2021/09/11)
The molecular hybridization concept led us to design a series of galloyl conjugates of flavanones that have potent osteoblast differentiation ability in vitro and promote bone formation in vivo. An array of in vitro studies, especially gene expression of
Chiral Hydroxytetraphenylene-Boron Complex Catalyzed Asymmetric Diels-Alder Cycloaddition of 2′-Hydroxychalcones
Chai, Guo-Li,Qiao, Yan,Zhang, Ping,Guo, Rong,Wang, Juan,Chang, Junbiao
supporting information, p. 8023 - 8027 (2020/11/02)
(S)-2,15-Cl2-DHTP-boron complex catalyst for the asymmetric Diels-Alder cycloaddition of 2′-hydroxychalcones and dienes was developed and tested. The resulting cyclohexenes with three chiral centers were obtained in high yields (up to 98%) with excellent stereoselectivities (up to >20:1 endo/exo, >99% ee). This catalytic system features high efficiency, broad substrate scopes, and mild reaction conditions. In addition, a DFT study was performed to explain the stereochemical course of the asymmetric induction.
Ionic liquid mediated Cu-catalyzed cascade oxa-Michael-oxidation: Efficient synthesis of flavones under mild reaction conditions
Du, Zhiyun,Ng, Huifen,Zhang, Kun,Zeng, Huaqiang,Wang, Jian
supporting information; experimental part, p. 6930 - 6933 (2011/11/04)
Flavonoids are a class of natural products, found in a wide range of vascular plants and dietary components. Their low toxicity and extensive biological activities, including anti-cancer and anti-bacterial, have made them attractive candidates to serve as therapeutic agents for many diseases. Herein, we disclose a highly efficient synthetic method of CuI-catalyzed cascade oxa-Michael-oxidation, using chalcones as substrates, mediated by the ionic liquid [bmim][NTf2] at a low temperature. This efficient synthetic method has demonstrated high synthetic utility and can afford flavones in good to high yields (up to 98%).
