177607-75-9

Upstream product

• 45214-52-6 (2S,3R)-3-acetoxy-2-(tert-butoxycarbonylamino)butanoic acid 
• 177607-73-7 (S)-2-[((2S,3R)-3-Acetoxy-2-tert-butoxycarbonylamino-butyryl)-methyl-amino]-3-methyl-butyric acid benzyl ester 
• 174224-63-6 tert-butyloxycarbonylthreonyl-N-methylvaline benzylester 
• 53363-89-6 N-t-butoxycarbonyl-N-methyl-L-leucine 

Downstream Products

• 141205-31-4 microcolin A 

Relevant academic research and scientific papers

Developing microcolin A analogs as biological probes

Three microcolin A and B analogs have been synthesized. Their biological activity profiles were evaluated against several cell lines, revealing the existence of a structural determinant whose role in mediating the antiproliferative effect of the microcoli

Total asymmetric synthesis of the potent immunosuppressive marine natural product microcolin A

The total asymmetric synthesis of the potent immunosuppressive compound microcolin A is reported. The synthesis establishes the absolute stereochemistry of microcolin A as C-36R, C-38R, and C-4S on the basis of the diastereoselective preparation of all four possible diastereomers of the lipid region (fragment A) and diastereoselective synthesis of fragment C starting from natural L-(S)-alanine. The strategy involves a convergent assemblage of three optically pure fragments and is amenable to chemical modifications to examine structural analogs for biological study.