45214-52-6

Upstream product

• 2592-18-9 tert-Butoxycarbonylamino-3-hydroxy-butyric acid 
• 33662-26-9 benzyl 2-(tert-butoxycarbonylamino)-3-hydroxybutanoate 
• 2592-18-9 Boc-Thr-OH 
• 75-36-5 acetyl chloride 
• 77313-56-5 Boc-Thr-ONbn 
• 254902-52-8 (2S,3R)-3-Acetoxy-2-tert-butoxycarbonylamino-butyric acid 4-nitro-benzyl ester 

Downstream Products

• 119603-16-6 majusculamide D 
• 141205-31-4 microcolin A 
• 177607-75-9 (S)-2-({(2S,3R)-3-Acetoxy-2-[(S)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-butyryl}-methyl-amino)-3-methyl-butyric acid benzyl ester 
• 177607-73-7 (S)-2-[((2S,3R)-3-Acetoxy-2-tert-butoxycarbonylamino-butyryl)-methyl-amino]-3-methyl-butyric acid benzyl ester 

Relevant academic research and scientific papers

Highly Convergent Total Synthesis and Assignment of Absolute Configuration of Majusculamide D, a Potent and Selective Cytotoxic Metabolite from Moorea sp.

The total synthesis of majusculamide D (MJS-D) is described, a lipopentapeptide originally isolated from Lyngbya majuscula and reisolated from a Moorea sp. MJS-D possesses selective and potent cancer cell toxicity. A scalable and convergent strategy with a minimal number of purifications produced significant quantities of MJM-D for in vivo evaluations. The absolute configuration of the 1,3-dimethyl-octanamide motif was determined by synthesis of this fragment via ZACA chemistry.

Pharmaceutical combination of an atypical antipsychotic and an NMDA modulator for the treatment of schizophrenia,bipolar disorder, cognitive impairment and major depressive disorder

This disclosure features combinations of NMDA modulators and atypical antipsychotics. The disclosure provides for example, methods of treating schizophrenia, bipolar disorder, and/or cognitive impairment disorder in a patient in need thereof, comprising administering e.g., rapastinel and an atypical antipsychotic.

Clickable glycopeptoids for synthesis of glycopeptide mimic

Structurally diverse novel glycopeptoids were synthesized which can be attached to biologically important peptides by click reaction to improve their potential to be used in medicinal chemistry. Triazole-linked αβ-hydrid glycopeptoids were synthesized that mimic the conserved linkage region of N-linked glycoproteins in eukaryotes. The amide bonds were replaced with triazole rings, and αβ-hybrid peptoids were introduced as the backbone modification in peptidomimetics. In addition to their facile synthesis, these modifications have the possibility of introducing otherwise impossible conformations in the peptide backbone.

Towards nucleopeptides containing any trifunctional amino acid

Nucleopeptides incorporating, besides the linking residue, other trifunctional amino acids such as lysine, arginine, tryptophan, serine, threonine and tyrosine have been obtained following stepwise solid-phase assembly. The best alternatives for the prote