177609-15-3

Usage

Uses

Used in Malaria Treatment:
C₄₃H₃₇N₃O₇ is used as an anti-malarial drug for treating and preventing malaria. It is effective in disrupting the function of parasites in red blood cells, leading to their death.
Used in Autoimmune Disease Treatment:
C₄₃H₃₇N₃O₇ is used as a potential treatment for autoimmune diseases such as rheumatoid arthritis and lupus. Its anti-inflammatory properties have been studied for their potential to alleviate symptoms and improve patient outcomes.
However, it is important to note that the use of C₄₃H₃₇N₃O₇ has been limited in recent years due to the development of drug-resistant strains of malaria and potential side effects such as retinopathy and cardiomyopathy. Despite these challenges, chloroquine remains an important drug in the fight against malaria and continues to be studied for its potential use in treating other conditions.

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 132327-80-1 Fmoc-L-Gln(Trt)-OH 

Relevant academic research and scientific papers

A facile synthesis and crystallographic analysis of N-protected β-amino alcohols and short peptaibols

A facile, efficient and racemization-free method for the synthesis of N-protected β-amino alcohols and peptaibols using N-hydroxysuccinimide active esters is described. Using this method, dipeptide, tripeptide and pentapeptide alcohols were isolated in high yields. The conformations in crystals of β-amino alcohol, dipeptide and tripeptide alcohols were analysed, with a well-defined type III β-turn being observed in the tripeptide alcohol crystals. This method is found to be compatible with Fmoc-, Boc- and other side-chain protecting groups.

Site-Specific Incorporation of Multiple Thioamide Substitutions into a Peptide Backbone via Solid Phase Peptide Synthesis

Among various peptide modification strategies, thioamide substitution by replacing the carbonyl oxygen atom of an amide bond with a sulfur atom constitutes an invaluable tool for chemical biology, for use in peptide drug discovery and protein structure-fu

NEW PEPTIDE-LINKED ESTER PRODRUGS ACTIVATED BY PROSTATE-SPECIFIC ANTIGEN

The present disclosure is directed to a series of target-selective chemotherapeutic ester prodrugs comprising PSA-cleavable peptides that promote the delivery of free doxorubicin and other chemotherapeutic agents into the prostate and/or prostate tumors with greater efficiency.