17765-66-1Relevant academic research and scientific papers
Modular Continuous Flow Synthesis of Imatinib and Analogues
Fu, Wai Chung,Jamison, Timothy F.
, p. 6112 - 6116 (2019)
A modular continuous flow synthesis of imatinib and analogues is reported. Structurally diverse imatinib analogues are rapidly generated using three readily available building blocks via a flow hydration/chemoselective C-N coupling sequence. The newly developed continuous flow hydration and amidation modules each exhibit a broad scope with good to excellent yields. Overall, the method described does not require solvent switches, in-line purifications, or packed-bed apparatuses due to the judicious manipulation of flow setups and solvent mixtures.
Substituted 2-anilinobenzoxazoles used as immunosuppressive agents
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, (2008/06/13)
Compositions comprising certain 2-(substituted anilino)benzoxazoles, such as 2-[4-bromo-3-(trifluoromethyl)anilino]benzoxazole, and methods for using same as immunosuppressive agents, antifertility agents, for the prophylaxis of Marek's disease in chicken
