177658-30-9Relevant academic research and scientific papers
The Direct Catalytic Asymmetric Cross-Mannich Reaction: A Highly Enantioselective Route to 3-Amino Alcohols and α-Amino Acid Derivatives
Cordova, Armando
, p. 1987 - 1997 (2007/10/03)
The first proline-catalyzed direct catalytic asymmetric one-pot, three-component cross-Mannich reaction has been developed. The highly chemoselective reactions between two different unmodified aldehydes and one aromatic amine are new routes to 3-amino ald
5(4'-Chloromethylphenyl)pentylpolystyrene resin (CMPP resin). A new linker resin for solid-phase organic synthesis under Lewis acidic conditions
Kobayashi, Shu,Moriwaki, Mitsuhiro
, p. 4251 - 4254 (2007/10/03)
A new linker resin for solid-phase organic synthesis under Lewis acidic conditions has been developed. The resin, 5-(4'-chloromethylphenyl)pentylpolystyrene resin (CMPP resin), has no oxygen or nitrogen atoms in its spacer moiety. Imino aldol reactions of polymer-supported silyl enol ethers using the new resin with imines were demonstrated in the presence of a Lewis acid, and it was shown that the yields using CMPP resin were much higher (ca. 10-30%) than those using Merrifield resin.
Parallel synthesis using Mannich-type three-component reactions and 'field synthesis' for the construction of an amino alcohol library
Kobayashi, Shu,Moriwaki, Mitsuhiro,Akiyama, Ryo,Suzuki, Shu,Hachiya, Iwao
, p. 7783 - 7786 (2007/10/03)
An amino alcohol library was constructed by parallel synthesis based on Mannich-type three-component reactions of aldehydes, amines, and polymer-supported silyl enol ethers, followed by reductive cleavage from the supports. 'Field Synthesis', which provid
Polymer-supported silyl enol ethers. Synthesis and reactions with imines for the preparation of an amino alcohol library
Kobayashi, Shu,Hachiya, Iwao,Suzuki, Shu,Moriwaki, Mitsuhiro
, p. 2809 - 2812 (2007/10/03)
Polymer-supported silyl enol ethers (thioketene silyl acetals) were prepared from chloromethyl copoly-(styrene-1%-divinylbenzene) resin. The silyl enol ethers reacted with imines in the presence of a catalytic amount of scandium triflate (Sc(OTf)3) to afford β-amino thioesters, which were reduced to amino alcohols in good yields. These reactions provide a convenient method for the preparation of an amino alcohol library.
