177665-49-5

Usage

Uses

Used in Pharmaceutical Research:
2-(3-(Hydroxymethyl)phenyl)acetonitrile is used as a building block in the synthesis of pharmaceuticals for its ability to contribute to the formation of more complex molecular structures. Its presence in the molecular framework can influence the properties and effectiveness of the final drug product.
Used in Agrochemical Synthesis:
In the agrochemical industry, 2-(3-(Hydroxymethyl)phenyl)acetonitrile is used as an intermediate in the synthesis of various agrochemicals. Its role in the formation of these compounds can contribute to the development of more effective and targeted pest control solutions.
Used in Organic Synthesis:
2-(3-(Hydroxymethyl)phenyl)acetonitrile is employed as a reactant in various organic synthesis processes. Its reactivity and functional group make it a valuable component in the creation of a wide range of organic compounds, from simple to complex structures.
Used in Industrial Chemical Processes:
2-(3-(Hydroxymethyl)phenyl)acetonitrile may also find application in industrial chemical processes, where it can act as a reactant or intermediate in the production of various chemical products. Its versatility and reactivity make it a useful component in the synthesis of a broad spectrum of industrial chemicals.

Upstream product

• 151-50-8 potassium cyanide 
• 82072-22-8 3-hydroxymethylbenzyl bromide 
• 68432-92-8 methyl 3-cyanomethylbenzoate 
• 99-36-5 1-methoxycarbonyl-3-methylbenzene 
• 1129-28-8 3-methoxycarbonylbenzyl bromide 
• 6515-58-8 3-bromomethylbenzoic acid 
• 123226-36-8 3-(bromomethyl)phenylacetonitrile 

Downstream Products

• 743384-09-0 (3-(2-aminoethyl)phenyl)methanol 
• 1292285-98-3 C₁₅H₂₁NO₅ 
• 1292285-60-9 C₁₂H₁₇NO₃ 
• 1621325-88-9 C₂₅H₃₀N₄O₄S₃ 
• 1621326-17-7 C₄₄H₄₄N₄O₄S₃ 
• 1621326-15-5 C₆₀H₅₈N₄O₇S₃ 
• 1621326-13-3 C₄₀H₃₉N₃O₄S₃ 
• 1621326-11-1 C₃₆H₃₇NO₂S₃ 
• 1621326-09-7 C₂₈H₂₄OS 
• 1621326-08-6 C₂₈H₂₃NS 
• 123226-36-8 3-(bromomethyl)phenylacetonitrile 

Relevant academic research and scientific papers

SEPIAPTERIN REDUCTASE INHIBITORS FOR THE TREATMENT OF PAIN

Disclosed herein are small molecule heterocyclic inhibitors of sepiapterin reductase (SPR), and pro-drugs and pharmaceutically acceptable salts thereof. The Also featured are pharmaceutical compositions of the compounds and uses of these compounds for the treatment or prevention of pain (e.g., inflammatory pain, nociceptive pain, functional pain, and neuropathic pain)

SUBSTITUTED PYRIDINONES

Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

Nucleophilic de-coordination and electrophilic regeneration of "hemilabile" pincer-type complexes: Formation of anionic dialkyl, diaryl, and dihydride PtII complexes bearing no stabilizing π-acceptors

Novel anionic dialkyl, diaryl, and dihydride platinum(II) complexes based on the new πlong-armπ hemilabile PCN-type ligand C6H 4[CH2P(tBu)2](CH2) 2N(CH3)2 with the general formula Li + [Pt(PCN)(R)2]- (R = Me (4), Ph (6) and H (9)) were prepared by reaction of [Pt(PCN)(R)] complexes (obtained from the corresponding chlorides) with an equivalent of RLi, as a result of the opening of the chelate ring. Alkylating agents based on other metals produce less stable products. These anionic d8 complexes are thermally stable although they bear no stabilizing π acceptors. They were characterized by 1H, 31P{1H}, 13C, and 7Li NMR spectroscopy; complex 9 was also characterized by single crystal X-ray crystallography, showing that the Li + ion is coordinated to the nitrogen atom of the open amine arm and to the hydride ligand (trans to the P atom) of a neighboring molecule (H-Li = 2.15 A), resulting in a dimeric structure. Complexes 4 and 9 exhibit high nucleophilic reactivity, upon which the pincer complex is regenerated. Reaction of 4 with water, methyl iodide, and iodobenzene resulted in the neutral complex [Pt(PCN)(CH3)] (3) and methane, ethane, or toluene, respectively. Labeling studies indicate that the reaction proceeds by direct electrophilic attack on the metal center, rather than attack on the alkyl ligand. The anionic dihydride complex 9 reacted with water and methyl iodide to yield [Pt(PCN)(H)] (8) and H2 or methane, respectively.