17768-29-5Relevant articles and documents
An adamantane-based disubstituted binding motif with picomolar dissociation constants for cucurbit[n]urils in water and related quaternary assemblies
Babjaková,Branná,Kuczyńska,Rouchal,Prucková,Dastychová,Vícha,Vícha
, p. 105146 - 105153 (2016)
A non-axial centerpiece based on 1,3-disubstituted adamantane was designed, and three new guests were prepared. In the structure of the heterotritopic guests, the central adamantane site was combined with two terminal butyl or 1-adamantyl sites. The new central binding motif displayed an extraordinarily high affinity towards CB8 (Ka = (5.3 ± 0.3) × 1012 M?1 in water) to allow formation of quaternary assemblies with geometries which are dependent on the nature of macrocycles. Based on the individual binding strengths, the replacement of CB7 by CB8 led to inverse arrangements of the quaternary assemblies; i.e., β-CD is capped at the central site by two CB7 units, while the CB8 prefers the central site to be capped with two β-CD units.
Compounds Useful for Promoting Protein Degradation and Methods Using Same
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Sheet 11, (2016/02/19)
The present description includes compounds that act as degraders of a target protein, wherein degradation is independent of the class of the target protein or its localization. In certain embodiments, the description includes a compound comprising a protein degradation moiety covalently bound to a linker, wherein the ClogP of the compound is equal to or higher than 1.5. The target protein contemplated within the description comprises an androgen receptor. Compounds of the present description may be used to treat disease states wherein protein degradation is a viable therapeutic approach, such as cancer or any sort of oxidative stress disease state.
