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177712-09-3

N-(4-toluenesulfonyl)-N'-phenyl-N'-carboxymethylurea is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 177712-09-3 Structure

  • Basic information

    1. Product Name: N-(4-toluenesulfonyl)-N'-phenyl-N'-carboxymethylurea
    2. Synonyms: N-(4-toluenesulfonyl)-N'-phenyl-N'-carboxymethylurea
    3. CAS NO:177712-09-3
    4. Molecular Formula:
    5. Molecular Weight: 348.379
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 177712-09-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-(4-toluenesulfonyl)-N'-phenyl-N'-carboxymethylurea(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-(4-toluenesulfonyl)-N'-phenyl-N'-carboxymethylurea(177712-09-3)
    11. EPA Substance Registry System: N-(4-toluenesulfonyl)-N'-phenyl-N'-carboxymethylurea(177712-09-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 177712-09-3(Hazardous Substances Data)

177712-09-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 177712-09-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,7,7,1 and 2 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 177712-09:
(8*1)+(7*7)+(6*7)+(5*7)+(4*1)+(3*2)+(2*0)+(1*9)=153
153 % 10 = 3
So 177712-09-3 is a valid CAS Registry Number.

177712-09-3Downstream Products

177712-09-3Relevant articles and documents

Substituted 3-(phenylsulfonyl)-1-phenylimidazolidine-2,4-dione derivatives as novel nonpeptide inhibitors of human heart chymase

Niwata,Fukami,Sumida,Ito,Kakutani,Saitoh,Suzuki,Imoto,Shibata,Imajo,Kiso,Tanaka,Nakazato,Ishihara,Takai,Yamamoto,Shiota,Miyazaki,Okunishi,Kinoshita,Urata,Arakawa

, p. 2156 - 2163 (2007/10/03)

A series of 3-(phenylsulfonyl)-1-phenylimidazolidine-2,4-dione derivatives have been synthesized and evaluated for their ability to selectively inhibit human heart chymase. The structureactivity relationship studies on these compounds gave the following results. The 1-phenyl moiety participates in a hydrophobic interaction where an optimum size is required. At this position, 3,4-dimethylphenyl is the best moiety for inhibiting chymase and showed high selectivity compared with chymotrypsin and cathepsin G. A 3-phenylsulfonyl moiety substituted with hydrogen-bend acceptors such as nitrile and methoxycarbonyl enhances its activity. Molecular-modeling studies on the interaction of 3-[(4-chlorophenyl)sulfonyl]-1-(4-chlorophenyl)- imidazolidine-2,4-dione (29) with the active site of human heart chymase suggested that the 1-phenyl moiety interacts with the hydrophobic P1 pocket, the 3-phenylsulfonyl moiety resides in the S1-S2 subsites, and the 4- carbonyl of the imidazolidine ring and sulfonyl group interact with the oxyanion hole and the His-45 side chain of chymase, respectively. The complex model is consistent with the structure-activity relationships.

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