177722-93-9

Upstream product

• 355-43-1 n-perfluorohexyl iodide 
• 177722-88-2 (2-Allyloxy-phenoxy)-tert-butyl-dimethyl-silane 
• 1126-20-1 2-allyloxyphenol 
• 120-80-9 benzene-1,2-diol 

Downstream Products

• 177722-92-8 2-(4,4,5,5,6,6,7,7,8,8,9,9,9-Tridecafluoro-2-iodo-nonyloxy)-phenol 

Relevant academic research and scientific papers

Sequential radical perfluoroalkylation - Nucleophilic cyclization. Synthesis of 2-perfluoroalkylidenemethyl and 2-perfluoroalkylmethyl-1,4-dioxanes from 1-O-allyl-1,2-diols

The title compounds were synthesized by radical addition of perfluoroalkyl iodide to 1-O-allyl-1,2-diols and subsequent nucleophilic cyclization according to one of the following procedures. Basic treatment of the iodo F-alkyl adduct gave an olefinic compound which is stereoselectively cyclized with an excess of base into the corresponding 2-perfluoroalkylidenemethyl-1,4-dioxane through as S(N)' process. The direct cyclization of the adduct into 2-perfluoroalkylmethyl-1,4-dioxane was achieved by a new and simple method using molecular iodine or positive halogen reagents (DBH, NBS) for the activation of the carbon-iodine bond.