177747-69-2

Upstream product

• 930-69-8 sodium thiophenolate 
• 108-98-5 thiophenol 
• 177747-62-5 (Z)-1,1,1-trifluoro-2-ethoxy-5-(4-methoxyphenyl)pent-2-ene 
• 63035-45-0 1-(2-ethyltriphenylphosphine)-4-methoxybenzene iodide 

Downstream Products

• 185682-65-9 3-Benzenesulfinyl-1,1,1-trifluoro-5-(4-methoxy-phenyl)-pentan-2-ol 

Relevant academic research and scientific papers

Synthesis of allylic trifluoromethyl alcohols from 1-trifluoromethyl-epoxy ethers

α-Thiophenyl ketones are easily available by the regioselective ring-opening of 1-trifluoromethyl-epoxy ethers with phenyl sodium thiolate. Their in situ reduction with NaBH4, followed by oxidation with NaIO4 and thermal decompositio

Synthesis of 3-(alkylthio and phenylthio)-1,1,1-trifluoroalkan-2-ones via ring opening of epoxy ethers

Regioselective ring opening of 1-trifluoromethyl epoxy ethers 2 was achieved with alkyl and phenyl sodium thiolates to afford new 3-(alkylthio and phenylthio)-1,1,1-trifluoroalkan-2-ones 3-5 in good yields.