177748-01-5Relevant articles and documents
Practical route to a new class of LTD4 receptor antagonists
Larsen, Robert D.,Corley, Edward G.,King, Anthony O.,Carroll, James D.,Davis, Paul,Verhoeven, Thomas R.,Reider, Paul J.,Labelle, Marc,Gauthier, Jacques Y.,Xiang, Yi Bin,Zamboni, Robert J.
, p. 3398 - 3405 (2007/10/03)
A general approach to the synthesis of a new class of LTD4 antagonists is presented. The key diarylpropane framework was prepared by Claisen-Schmidt condensation and selective reduction of the enone. Depending on the bridge to the 7-chloroquinaldine moiety, alkylation or Heck coupling methodology was developed. The chiral sulfides were introduced by asymmetric reduction of the diarylpropanone intermediates and subsequent inversion of the chiral center.
