177753-10-5Relevant articles and documents
Synthesis of 2S-[2-2H]-kynurenine and use in kinetic isotope effect studies with kynureninase
Ross, Fiona C.,Botting, Nigel P.,Leeson, Paul D.
, p. 15761 - 15770 (2007/10/03)
2S-[2-2H]-Kynurenine has been synthesised by two different routes. Diacetylation/racemisation of racemic kynurenine in deuterium oxide followed by acylase catalysed resolution provides the most direct method. The alternative is to prepare 2S-[2-2H]-tryptophan by a similar procedure and then convert this through to 2S-[2-2H]-kynurenine via ozonolysis. Preliminary results on measurements of the primary deuterium isotope effect, and solvent isotope effect, are described.