201049-00-5

Basic information

• Product Name: N'-formyl,N-(benzyloxycarbonyl)-(2S)-(2-⁽²⁾H)-kynurenine ethyl ester
• Synonyms: N'-formyl,N-(benzyloxycarbonyl)-(2S)-(2-⁽²⁾H)-kynurenine ethyl ester
• CAS NO: 201049-00-5
• Molecular Weight: 399.408
• Mol File: 201049-00-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N'-formyl,N-(benzyloxycarbonyl)-(2S)-(2-⁽²⁾H)-kynurenine ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N'-formyl,N-(benzyloxycarbonyl)-(2S)-(2-⁽²⁾H)-kynurenine ethyl ester(201049-00-5)
• EPA Substance Registry System: N'-formyl,N-(benzyloxycarbonyl)-(2S)-(2-⁽²⁾H)-kynurenine ethyl ester(201049-00-5)

Safety Data

• Hazardous Substances Data: 201049-00-5(Hazardous Substances Data)

Upstream product

• 177753-04-7 C₁₃H₁₅⁽²⁾HN₂O₂ 
• 54-12-6 Trp 
• 81279-11-0 (2-²H)-L-tryptophan 
• 80525-43-5 N-acetyl (2SR)-(2-⁽²⁾H)-tryptophan 
• 501-53-1 benzyl chloroformate 
• 177753-05-8 N-(benzyloxycarbonyl)-(2S)-(2-⁽²⁾H)-tryptophan ethyl ester 

Downstream Products

• 177753-06-9 2S-[2-²H]-kynurenine 
• 177753-11-6 N-(benzyloxycarbonyl)-(2S)-(2-⁽²⁾H)-kynurenine 
• 177753-10-5 N-(benzyloxycarbonyl)-(2S)-(2-⁽²⁾H)-kynurenine ethyl ester 

Relevant articles and documents

Synthesis of 2S-[2-2H]-kynurenine and use in kinetic isotope effect studies with kynureninase

2S-[2-2H]-Kynurenine has been synthesised by two different routes. Diacetylation/racemisation of racemic kynurenine in deuterium oxide followed by acylase catalysed resolution provides the most direct method. The alternative is to prepare 2S-[2-2H]-tryptophan by a similar procedure and then convert this through to 2S-[2-2H]-kynurenine via ozonolysis. Preliminary results on measurements of the primary deuterium isotope effect, and solvent isotope effect, are described.