177789-65-0

Upstream product

• 74002-88-3 ethyl p-(1-imidazolylmethyl) cinnamate 
• 75-65-0 tert-butyl alcohol 
• 78712-80-8 ethyl (E)-3-[4-(imidazol-1-ylmethyl)phenyl]acrylate 

Relevant academic research and scientific papers

4-(1-imidazolylmethyl)cinnamic acid hydrochloride monohydrate and pharmaceutical compositions

4-(1-Imidazolylmethyl)cinnamic acid hydrochloride monohydrate of the formula: STR1 and pharmaceutical compositions containing such compound. The imidazole derivative above has a strong and specific inhibitory effect on thromboxane synthetase from human or

Imidazole derivative

Novel imidazole derivatives of the general formula (I): STR1 wherein Y is a carboxyl group, an alkoxycarbonyl group, a cyano group, a hydroxymethyl group, an aminomethyl group, a formyl group or a carbamoyl group, and A and B, which may be the same or different, each is a straight- or branched-chain alkylene or alkenylene group, and n and m, which may be the same or different, each is zero or 1, with the proviso that when A is methylene group or n is zero, m is 1; and pharmaceutically acceptable salts thereof. These compounds have a strong inhibitory effect on thromboxane synthetase from rabbit platelet microsomes, and are useful as therapeutically active agents for the treatment of inflammation, hypertension, thrombus, cerebral apoplexy and asthma.