17780-72-2

Basic information

• Product Name: CLORGYLINE
• Synonyms: clorgiline;m&b9302;mandb9302;n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propyn-1-amin;n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propynylamin;N-[3-(2,4-Dichlorophenoxy)propyl]-N-methyl-2-propyn-1-amine;N-Methyl-N-[3-(2,4-dichlorophenoxy)propyl]-2-propyne-1-amine;2-Propyn-1-aMine, N-[3-(2,4-dichlorophenoxy)propyl]-N-Methyl-
• CAS NO: 17780-72-2
• Molecular Formula: C₁₃H₁₅Cl₂NO
• Molecular Weight: 272.1703
• Mol File: 17780-72-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 361.3°Cat760mmHg
• Flash Point: 172.3°C
• Appearance: /
• Density: 1.196g/cm³
• Vapor Pressure: 2.1E-05mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: CLORGYLINE(CAS DataBase Reference)
• NIST Chemistry Reference: CLORGYLINE(17780-72-2)
• EPA Substance Registry System: CLORGYLINE(17780-72-2)

Safety Data

• Hazardous Substances Data: 17780-72-2(Hazardous Substances Data)

Usage

Definition

ChEBI: An aromatic ether that is the 2,4-dichlorophenyl ether of 3-aminopropan-1-ol in which the nitrogen is substituted by a methyl group and a prop-1-yn-3-yl group. A monoamine oxidase inhibitor, it was formerly used as an antidepressant.

InChI:InChI=1/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3

Upstream product

• 35113-90-7 2,4-dichloro-N,N-dimethylaniline 
• 85507-24-0 N-methyl-3-(2,4-dichlorophenoxy)propylamine 
• 106-96-7 propargyl bromide 
• 120-83-2 2,4-dichlorophenol 
• 62505-89-9 5-{[3-(2,4-Dichloro-phenoxy)-propyl]-methyl-amino}-2-methyl-pent-3-yn-2-ol 
• 35161-71-8 methyl(propargyl)amine 
• 6954-78-5 1-bromo-3-(2,4-dichlorophenoxy)propane 

Relevant articles and documents

From Anilines to Aryl Ethers: A Facile, Efficient, and Versatile Synthetic Method Employing Mild Conditions

We have developed a simple and direct method for the synthesis of aryl ethers by reacting alcohols/phenols (ROH) with aryl ammonium salts (ArNMe3+), which are readily prepared from anilines (ArNR′2, R′=H or Me). This reaction proceeds smoothly and rapidly (within a few hours) at room temperature in the presence of a commercially available base, such as KOtBu or KHMDS, and has a broad substrate scope with respect to both ROH and ArNR′2. It is scalable and compatible with a wide range of functional groups.

2-Methyl-3-butyn-2-ol as an acetylene precursor in the Mannich reaction. A new synthesis of suicide inactivators of monoamine oxidase.

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