17782-05-7

Basic information

• Product Name: 2-(2-methyl-anilino)-nicotinic acid
• Synonyms: 2-(2-methyl-anilino)-nicotinic acid;Dechloro Chlonixin
• CAS NO: 17782-05-7
• Molecular Formula: C₁₃H₁₂N₂O₂
• Molecular Weight: 228.25
• Mol File: 17782-05-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 167-168 °C
• Boiling Point: 391.9±32.0 °C(Predicted)
• Appearance: /
• Density: 1.285±0.06 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 1.73±0.36(Predicted)
• CAS DataBase Reference: 2-(2-methyl-anilino)-nicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-methyl-anilino)-nicotinic acid(17782-05-7)
• EPA Substance Registry System: 2-(2-methyl-anilino)-nicotinic acid(17782-05-7)

Safety Data

• Hazardous Substances Data: 17782-05-7(Hazardous Substances Data)

Usage

Uses

Dechloro Chlonixin is a derivative of the drug Chlonixin (C587140). Clonixin is a non-steroidal anti-inflammatory drug. It also has analgesic, antipyretic, and platelet-inhibitory actions. The compound has been reported to block prostaglandin synthesis, and to block inward calcium currents.

Upstream product

• 2942-59-8 2-chloronicotinic acid 
• 95-53-4 o-toluidine 

Downstream Products

• 115891-93-5 3-Butyl-4-hydroxy-1-o-tolyl-1H-[1,8]naphthyridin-2-one 
• 114501-03-0 2-o-Tolylamino-nicotinic acid methyl ester 

Relevant articles and documents

Substituent Electronegativity and Isostructurality in the Polymorphism of Clonixin Analogues

To gain understanding of how the variation in local weak interactions influences intermolecular interactions and subsequent crystal packing, four analogues of 2-(3-chloro-2-methyl-phenylamino)-nicotinic acid [clonixin] were synthesized by replacing the ch

Catalyst-free amination of 2-chloronicotinic acid in water under microwave irradiation

A simple, efficient and environmental friendly method for the synthesis of 2-arylaminonicotinic acids derivatives by reacting 2-chloronicotinic acid with anilines with potassium carbonate as the base and water as the media under microwave irradiation is described. The synthesis of 2-arylaminonicotinic acids is important because they are nonsteroidal anti-inflammatory drugs.