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Usage

Uses

Used in Pharmaceutical Industry:
2-(2-methyl-anilino)-nicotinic acid is used as an active pharmaceutical ingredient for its anti-inflammatory, analgesic, antipyretic, and platelet-inhibitory actions. The compound is effective in blocking prostaglandin synthesis and inhibiting inward calcium currents, making it a valuable candidate for the development of new drugs targeting inflammation and pain.
Used in Chemical Research:
In the field of chemical research, 2-(2-methyl-anilino)-nicotinic acid serves as a key intermediate in the synthesis of various complex organic molecules. Its unique structure allows for further functionalization and modification, leading to the development of novel compounds with potential applications in different industries.
Used in Material Science:
The compound's ability to interact with other molecules makes it a candidate for use in material science, particularly in the development of new materials with specific properties. Its potential applications may include the creation of advanced polymers, sensors, or other functional materials.

Upstream product

• 2942-59-8 2-chloronicotinic acid 
• 95-53-4 o-toluidine 

Downstream Products

• 115891-93-5 3-Butyl-4-hydroxy-1-o-tolyl-1H-[1,8]naphthyridin-2-one 
• 114501-03-0 2-o-Tolylamino-nicotinic acid methyl ester 

Relevant academic research and scientific papers

Substituent Electronegativity and Isostructurality in the Polymorphism of Clonixin Analogues

To gain understanding of how the variation in local weak interactions influences intermolecular interactions and subsequent crystal packing, four analogues of 2-(3-chloro-2-methyl-phenylamino)-nicotinic acid [clonixin] were synthesized by replacing the ch

Synthesis of 2-(arylamino)nicotinic acids in high-temperature water

In hydrothermal reactions at 150-180 °C, 2-(arylamino)nicotinic acids were synthesized by amination of 2-chloronicotinic acid with aromatic amine derivatives, with potassium carbonate as base. The procedure is efficient, environmentally friendly, and practical, with moderate to excellent yields (up to 98%). Springer Science+Business Media B.V. 2012.

Catalyst-free amination of 2-chloronicotinic acid in water under microwave irradiation

A simple, efficient and environmental friendly method for the synthesis of 2-arylaminonicotinic acids derivatives by reacting 2-chloronicotinic acid with anilines with potassium carbonate as the base and water as the media under microwave irradiation is described. The synthesis of 2-arylaminonicotinic acids is important because they are nonsteroidal anti-inflammatory drugs.

Antiallergy Agents. 1. Substituted 1,8-Naphthyridin-2(1H)-ones as Inhibitors of SRS-A Release

A novel class of antiallergy agents, the substituted 1,8-naphthyridin-2(1H)-ones, is described.The present compounds are orally active, potent inhibitors of allergic and nonallergic bronchospasm in animal models.Structure-activity studies of the lead compound in this sereis, 1-phenyl-3-n-butyl-4-hydroxynaphthyridin-2(1H)-one (11), identified three compounds of interest, 1-phenyl-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one (12), 1-(3'-chlorophenyl)-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one (87), and 1-(3'-methoxyphenyl)-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one (89).The mechanism of antiallergy activity may involve inhibition of the release of the sulfidopeptide leukotrienes. 1-Phenyl-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one, Sch 33303 (12), was selected for preclinical development as an antiallergy agent.