17785-40-9

Upstream product

• 5153-67-3 nitrostyrene 
• 147-93-3 Thiosalicylic acid 
• 17785-37-4 2-((2-nitro-1-phenylethyl)thio)benzoic acid 
• 17785-38-5 2-((2-nitro-1-phenylethyl)sulfanyl)benzoic acid methyl ester 
• 5962-00-5 2-phenyl-thiochroman-4-one 
• 26643-00-5 2-((2-amino-1-phenylethyl)sulfanyl)benzoic acid methyl ester 

Downstream Products

• 16711-04-9 4-(2-diethylamino-ethyl)-2-phenyl-3,4-dihydro-2H-benzo[f][1,4]thiazepin-5-one 
• 17749-73-4 4-(2-dimethylamino-ethyl)-2-phenyl-3,4-dihydro-2H-benzo[f][1,4]thiazepin-5-one 

Relevant academic research and scientific papers

3,4-dihydrogen-benzo[f][1,4] thiazepine*-5(2H)-ketones and their applications in medicine

The invention belongs to the technical field of medicine and relates to 3,4-dihydrogen-benzo[f][1,4] thiazepine*-5(2H)-ketones with the general structure of formula I and their applications in medicine. These compounds selectively inhibit the activity of glycogen synthesis kinases-3 beta (GSK 3beta), which can be used to prepare medicaments for preventing and/or treating diseases having GSK 3betaabnormal pathological characteristics, such as cancer, neurological diseases, inflammation, metabolic syndrome, and the like.

Benzodiazepine analogues. Part 8. Trimethylsilyl azide mediated Schmidt rearrangement of thioflavanone and thiochromanone precursors

The synthesis and Schmidt rearrangement of a series of thioflavanone analogues to benzothiazepinone derivatives is described.

OXAZEPINES AND THIAZEPINES, XI. THE SCHMIDT REACTION OF 1-THIOFLAVANONE

2,3-dihydro-2-phenyl-1,4-benzothiazepin-5(4H)-one (I) and 2,3-dihydro-2-phenyl-1,5-benzothiazepin-4(5H)-one (II) were synthesized via the Schmidt reaction of 1-thioflavanone