26643-00-5Relevant academic research and scientific papers
3,4-dihydrogen-benzo[f][1,4] thiazepine*-5(2H)-ketones and their applications in medicine
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Paragraph 0027; 0038; 0039; 0040, (2019/11/20)
The invention belongs to the technical field of medicine and relates to 3,4-dihydrogen-benzo[f][1,4] thiazepine*-5(2H)-ketones with the general structure of formula I and their applications in medicine. These compounds selectively inhibit the activity of glycogen synthesis kinases-3 beta (GSK 3beta), which can be used to prepare medicaments for preventing and/or treating diseases having GSK 3betaabnormal pathological characteristics, such as cancer, neurological diseases, inflammation, metabolic syndrome, and the like.
