17790-50-0

Usage

Uses

Used in Chemical Synthesis:
2-(3-CHLOROPHENYL)PROPAN-2-AMINE HYDROCHLORIDE is used as a reagent for the synthesis of alkoxycarbonyl(aryl)dihydropyrrolone derivatives, which possess herbicidal activity. Its unique structure allows it to participate in various chemical reactions, making it a valuable component in the development of new compounds with potential applications in agriculture and other industries.
Used in Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, 2-(3-CHLOROPHENYL)PROPAN-2-AMINE HYDROCHLORIDE, due to its structural properties, may also find applications in the pharmaceutical industry. It could potentially be used as an intermediate in the synthesis of various drugs, targeting specific biological pathways or receptors.
Used in Research and Development:
In the field of research and development, 2-(3-CHLOROPHENYL)PROPAN-2-AMINE HYDROCHLORIDE can be employed as a starting material or a building block for creating novel compounds with diverse applications. Its reactivity and structural features make it a promising candidate for exploring new chemical entities with potential uses in various industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 100-18-5 1,4-bis(1-methylethyl)benzene 
• 64798-37-4 m-chloro-α,α-dimethylbenzyl isocyanate 
• 17797-13-6 5-(2-Aminoprop-2-yl)-2-isopropylchlorbenzol 
• 31002-87-6 2-(3-chlorophenyl)propan-2-ol 
• 49841-53-4 1-chloro-2,5-diisopropylbenzene 
• 99-02-5 3'-Chloroacetophenone 

Downstream Products

• 21317-36-2 2,2'-Di-(m-chlor-phenyl)-<2,2'>azopropan 
• 97872-10-1 2-Benzo[d]isoxazol-3-yl-N-[1-(3-chloro-phenyl)-1-methyl-ethyl]-acetamide 
• 153197-69-4 N-methylene-1-methyl-1-(3-chlorophenyl)ethylamine 
• 130416-45-4 2-(2,5-dichlorophenyl)propan-2-amine 
• 848031-09-4 1-[1-(3-chloro-phenyl)-1-methyl-ethyl]-3-(2-fluoro-phenyl)-4-methyl-pyrrole-2,5-dione 

Relevant academic research and scientific papers

One-Pot C-H Arylation/Lactamization Cascade Reaction of Free Benzylamines

An efficient method has been developed for the synthesis of seven-membered biaryl lactams involving Pd-catalyzed, native amine-directed, ortho-arylation of benzylamines followed by in situ lactamization. This cascade sequence is enabled by the use of 2-iodobenzoates, which facilitates C-H arylation from the free amine under conditions that typically require an improved directing group approach. This reaction is characterized by a broad substrate scope with good functional group tolerance. The need for an ester versus carboxylic acid-functionalized coupling partner is also explored, as is the potential for synthesizing eight-membered biaryl lactams. Various applications are also investigated, including access to the aza-brassinolide core.

Carbon Dioxide-Mediated C(sp2)-H Arylation of Primary and Secondary Benzylamines

C-C bond formation by transition metal-catalyzed C-H activation has become an important strategy to fabricate new bonds in a rapid fashion. Despite the pharmacological importance of ortho-arylbenzylamines, however, effective ortho-C-C bond formation of free primary and secondary benzylamines using PdII remains an outstanding challenge. Presented herein is a new strategy for constructing ortho-arylated primary and secondary benzylamines mediated by carbon dioxide (CO2). The use of CO2 with Pd is critical to allowing this transformation to proceed under relatively mild conditions, and mechanistic studies indicate that it (CO2) is directly involved in the rate-determining step. Furthermore, the milder temperatures furnish free amine products that can be directly used or elaborated without the need for deprotection. In cases where diarylation is possible, an interesting chelate effect is shown to facilitate selective monoarylation.

NITROGEN-CONTAINING SATURATED HETEROCYCLIC COMPOUND

The present invention provides a compound represented by the following formula (I) or its pharmaceutically acceptable salt: [wherein, R1 represents optionally substituted C1-4 alkyl, n shows integer of 1 to 4, R2 represents optionally substituted C1-4 alkyl or hydrogen atom, R3 represents optionally substituted C1-4 alkyl, R4a, R4b, R4c, and R4d, similarly or differently, represent optionally substituted C6-14 aryl, optionally substituted C1-4 alkyl, or hydrogen atom and the like, A represents optionally substituted C6-14 aryl or optionally substituted 5 to 11 membered heteroaryl].

Synthesis and Herbicidal Activities of 1,2-Benzisoxazole-3-acetamide Derivatives

Many 1,2-benzisoxazole-3-acetamides were synthesized and their herbicidal activities in the paddy field were studied.Of the compounds tested, N-α,α-dimethylbenzyl-2-bromo-(1,2-benzisoxazol-3-yl)acetamide 10a was the most effective.Details of the synthesis and the results of herbicidal evaluations are given.