177900-52-6Relevant academic research and scientific papers
Asymmetric ring opening of epoxides with cyanides catalysed by chiral binuclear titanium complexes
Maleev, Victor I.,Chusov, Denis A.,Yashkina, Lidiya V.,Ikonnikov, Nikolai S.,Il'In, Michail M.
, p. 838 - 843 (2014/06/23)
A series of Schiff bases obtained from salicylaldehydes and 3,3′-diformyl-BINOL were synthesized. The complexes of these Schiff bases with Ti(IV) were active for the asymmetric ring opening of epoxides with TMSCN. A mixture of unpurified ligands was found
Asymmetric meso-epoxide ring-opening with trimethylsilyl cyanide promoted by chiral binuclear complexes of titanium. Dichotomy of C-C versus C-N bond formation
Belokon, Yuri N.,Chusov, Denis,Peregudov, Alexander S.,Yashkina, Lidia V.,Timofeeva, Galina I.,Maleev, Victor I.,North, Michael,Kagan, Henri B.
scheme or table, p. 3157 - 3167 (2010/07/03)
In the presence of chiral catalysts derived from the same chiral hexadentate ligand and aluminium, zinc or titanium ions, the reaction between cyclohexene oxide and trimethylsilyl cyanide can be controlled to give predominantly either the nitrile (up to 99% ee) or the isonitrile product (up to 94% ee). The metal ion, ligand stereochemistry and base concentration all play a role in determining the product ratio.
