17794-34-2

Upstream product

• 1484-26-0 3-(benzyloxy)aniline 
• 1268821-42-6 N,N-bis(2-(methylsulfonyloxy)ethyl)-3-benzyloxyaniline 
• 6373-46-2 p-benzyloxyaniline 
• 20012-18-4 N,N-bis(2-hydroxyethyl)-3-benzyloxyaniline 

Downstream Products

• 52177-45-4 m-(Bis-2-Chlorethylamino)phenol 
• 1268821-45-9 C₂₅H₂₇N₂O⁽¹⁺⁾*Cl^(1-) 
• 1268821-34-6 4'-(3-hydroxyphenyl)spiro[indoline-1,1'-piperazin]-1-ium chloride 

Relevant academic research and scientific papers

Synthesis and structure-analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ)

A series of monospirocyclopiperazinium salts were designed and synthesized to search for a peripherally-acting analgesic drug with low side effects. Extensive SAR studies revealed that a suitable NR2R3 was critical for the analgesic activity, which might be beneficial to expose the cationic nitrogen to bind to the receptor, and possibly interact with the receptor via π-π interaction. Introduction of substituting group on the N4-phenyl ring could improve the activity, and the best position was the 4-position. Compound 14n showed more potent analgesic activity (63%, 20 μM/kg, sc) and holds promise for development as a mechanically new analgesic drug.