20012-18-4

Basic information

• Product Name: N,N-bis(2-hydroxyethyl)-3-benzyloxyaniline
• Synonyms: N,N-bis(2-hydroxyethyl)-3-benzyloxyaniline
• CAS NO: 20012-18-4
• Molecular Weight: 287.359
• Mol File: 20012-18-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N,N-bis(2-hydroxyethyl)-3-benzyloxyaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-bis(2-hydroxyethyl)-3-benzyloxyaniline(20012-18-4)
• EPA Substance Registry System: N,N-bis(2-hydroxyethyl)-3-benzyloxyaniline(20012-18-4)

Safety Data

• Hazardous Substances Data: 20012-18-4(Hazardous Substances Data)

Upstream product

• 1484-26-0 3-(benzyloxy)aniline 
• 107-07-3 2-chloro-ethanol 
• 75-21-8 oxirane 
• 6373-46-2 p-benzyloxyaniline 

Downstream Products

• 1268821-34-6 4'-(3-hydroxyphenyl)spiro[indoline-1,1'-piperazin]-1-ium chloride 
• 1268821-45-9 C₂₅H₂₇N₂O⁽¹⁺⁾*Cl^(1-) 
• 1268821-42-6 N,N-bis(2-(methylsulfonyloxy)ethyl)-3-benzyloxyaniline 
• 52177-45-4 m-(Bis-2-Chlorethylamino)phenol 
• 17794-34-2 N,N-bis(2-chloroethyl)-3-benzyloxyaniline 

Relevant articles and documents

Synthesis and structure-analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ)

A series of monospirocyclopiperazinium salts were designed and synthesized to search for a peripherally-acting analgesic drug with low side effects. Extensive SAR studies revealed that a suitable NR2R3 was critical for the analgesic activity, which might be beneficial to expose the cationic nitrogen to bind to the receptor, and possibly interact with the receptor via π-π interaction. Introduction of substituting group on the N4-phenyl ring could improve the activity, and the best position was the 4-position. Compound 14n showed more potent analgesic activity (63%, 20 μM/kg, sc) and holds promise for development as a mechanically new analgesic drug.