177944-29-5Relevant academic research and scientific papers
Chiral Analogues of PFI-1 as BET Inhibitors and Their Functional Role in Myeloid Malignancies
Altenburg, Bianca,Frings, Marcus,Sch?bel, Jan-Hendrik,Go?en, Jonas,Pannen, Kristina,Vanderliek, Kim,Rossetti, Giulia,Koschmieder, Steffen,Chatain, Nicolas,Bolm, Carsten
supporting information, p. 1928 - 1934 (2020/11/09)
Structural analogues of PFI-1 varying at the sulfur core were prepared, and their activities as BET inhibitors in myeloid cell lines and primary cells from patients with acute myeloid leukemia were studied. Docking calculations followed by molecular dynam
Sulfoximine-titanium reagents in enantioselective trimethylsilylcyanations of aldehydes
Bolm, Garsten,Mueller, Peter,Harms, Klaus
, p. 305 - 315 (2007/10/03)
Chiral titanium reagents derived from optically active sulfoximines and Ti(O-i-Pr)4 promote the asymmetric addition of trimethysilyl cyanide to aldehydes affording cyanohydrins in high yields with good enantioselectivities (up to 91% ee). The ligand structure and the reaction conditions have been optimized. With substoichiometric amounts of the sulfoximine-titanium reagent the product is obtained in decreased yield with lower enantiomeric excess. The molecular structures of (R)-S-(2-hydroxypheny)-S-methyl sulfoximine [(R)-4a] and (R)-S-(2-hydroxyphenyl)-S-(1.1-dimethylethyl) sulioximine [(R)-4d) have been determined by X-ray diffraction analysis. Acta Chemica Scandinavica 1996.
