177948-33-3Relevant articles and documents
Preparation method of 2-amino-2-(1-methyl-4-piperidyl)ethanol
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, (2021/07/24)
The invention discloses a preparation method of 2-amino-2-(1-methyl-4-piperidyl) ethanol. The preparation method comprises the following steps: reacting 2-methyl-2-propyl-4-(1-amino-2-methoxy-2-oxoethyl)-1-piperidinecarboxylate (a compound II) with benzyl bromide under the action of an alkali 1 to generate a compound III; dissolving the compound III in an organic solvent, and generating a compound IV under the action of a reducing agent; and removing benzyl from the compound IV under the action of a catalyst/hydrogen to generate a compound I.
Compound, pharmaceutically acceptable salt thereof and medical application thereof
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, (2020/07/24)
The invention belongs to the field of medicines, and particularly relates to a compound shown as a formula I or medicinal salt thereof. The invention also relates to application of the compound or themedicinal salt thereof in selectively inhibiting LF activity, resisting anthrax toxin toxicity and preventing or treating anthracnose.
The discovery of novel cyclohexylamide CCR2 antagonists
Lanter, James C.,Markotan, Thomas P.,Zhang, Xuqing,Subasinghe, Nalin,Kang, Fu-An,Hou, Cuifen,Singer, Monica,Opas, Evan,McKenney, Sandra,Crysler, Carl,Johnson, Dana,Molloy, Christopher J.,Sui, Zhihua
, p. 7496 - 7501 (2012/02/13)
As a result of further SAR studies on a piperidinyl piperidine scaffold, we report the discovery of compound 44, a potent, orally bioavailable CCR2 antagonist. While having some in vitro hERG activity, this molecule was clean in an in vivo model of QT pro