175213-46-4

Basic information

• Product Name: METHYL 1-BOC-4-PIPERIDINEACETATE
• Synonyms: N-BOC-4-PIPERIDINEACETIC ACID METHYL ESTER;METHYL 1-BOC-4-PIPERIDINEACETATE;t-Butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate;Methyl N-Boc-4-piperidineacetate Methyl 1-Boc-4-piperidineacetate 4-((Methoxycarbonyl)methyl)piperidine-1-carboxylic acid tert-butyl ester;tert-butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate;1-Boc-4-Piperidine acetate methyl ester;1-Boc-4-Piperidine acetic acid methyl ester;Methyl 1-N-Boc-4-piperidineacetate
• CAS NO: 175213-46-4
• Molecular Formula: C₁₃H₂₃NO₄
• Molecular Weight: 257.33
• Product Categories: Amines;blocks;Carboxes;pharmacetical
• Mol File: 175213-46-4.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 323.1 °C at 760 mmHg
• Flash Point: 149.2 °C
• Appearance: /
• Density: 1.062 g/cm³
• Vapor Pressure: 0.000267mmHg at 25°C
• Refractive Index: 1.466
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -1.88±0.40(Predicted)
• CAS DataBase Reference: METHYL 1-BOC-4-PIPERIDINEACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 1-BOC-4-PIPERIDINEACETATE(175213-46-4)
• EPA Substance Registry System: METHYL 1-BOC-4-PIPERIDINEACETATE(175213-46-4)

Safety Data

• Hazardous Substances Data: 175213-46-4(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C13H23NO4/c1-13(2,3)18-12(16)14-7-5-10(6-8-14)9-11(15)17-4/h10H,5-9H2,1-4H3

Upstream product

• 67-56-1 methanol 
• 89151-44-0 4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 168986-49-0 4-piperidine acetic acid methyl ester 
• 81270-37-3 methyl piperidine-4-acetate hydrochloride 
• 865-33-8 potassium methanolate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 7440-44-0 pyrographite 
• 7440-05-3 palladium 
• 169206-65-9 1-tert-butoxycarbonyl-4-[(methoxycarbonyl)methylene]piperidine 
• 157688-46-5 2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 81270-37-3 methyl piperidine-4-acetate hydrochloride 
• 183170-69-6 1-tert-Butyloxycarbonyl-4-hydroxyethyl-piperidine 
• 881016-89-3 4-(bromo-carboxy-methyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 622-26-4 4-(2-Hydroxyethyl)piperidine 
• 960391-50-8 C₂₆H₃₅F₂N₃O₃ 
• 960391-38-2 methyl [1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidin-4-yl]acetate 
• 423722-27-4 2-(1-(methylsulfonyl)piperidin-4-yl)acetic acid 
• 861451-20-9 tert-butyl 4-(1-methoxy-2-methyl-1-oxopropan-2-yl)piperidine-1-carboxylate 
• 1352485-19-8 R,S-2-[4-(1H-indol-3-yl)-trans-cyclohexylamino]-2-[1-(trans-3,5-difluorocinnamoyl)piperidin-4-yl]-acetamide 

Relevant articles and documents

Oxidative esterification of alcohols by a single-side organically decorated Anderson-type chrome-based catalyst

The direct esterification of alcohols with non-noble metal-based catalytic systems faces great challenges. Here, we report a new chrome-based catalyst stabilized by a single pentaerythritol decorated Anderson-type polyoxometalate, [N(C4H9)4]3[CrMo6O18(OH)3C{(OCH2)3CH2OH}], which can realize the efficient transformation from alcohols to esters by H2O2oxidation in good yields and high selectivity without extra organic ligands. A variety of alcohols with different functionalities including some natural products and pharmaceutical intermediates are tolerated in this system. The chrome-based catalyst can be recycled several times and still keep the original configuration and catalytic activity. We also propose a reasonable catalytic mechanism and prove the potential for industrial applications.

Conversion of alcohols to alkyl esters and carboxylic acids using heterogeneous palladium-based catalysts

Disclosed are methods for synthesizing an ester or a carboxylic acid from an organic alcohol. To form the ester one reacts, in the presence of oxygen gas, the alcohol with methanol or ethanol. This reaction occurs in the presence of a catalyst comprising palladium and a co-catalyst comprising bismuth, tellurium, lead, cerium, titanium, zinc and/or niobium (most preferably at least bismuth and tellurium). Alternatively that catalyst can be used to generate an acid from that alcohol, when water is also added to the reaction mix.

INHIBITORS OF RENAL OUTER MEDULLARY POTASSIUM CHANNEL

Disclosed are compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.