177948-71-9

Basic information

• Product Name: N-benzyl-N-(4-piperidinylmethyl)amine
• Synonyms: N-benzyl-N-(4-piperidinylmethyl)amine
• CAS NO: 177948-71-9
• Molecular Formula: C₁₃H₂₀N₂
• Molecular Weight: 204.3113
• Mol File: 177948-71-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-benzyl-N-(4-piperidinylmethyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-N-(4-piperidinylmethyl)amine(177948-71-9)
• EPA Substance Registry System: N-benzyl-N-(4-piperidinylmethyl)amine(177948-71-9)

Safety Data

• Hazardous Substances Data: 177948-71-9(Hazardous Substances Data)

Upstream product

• 71207-29-9 N-hexahydro-4-pyridinylmethyl-N-phenylmethylidenamine 
• 7144-05-0 4-Aminomethylpiperidine 
• 100-52-7 benzaldehyde 
• 101264-48-6 4-(phenylmethylaminocarbonyl)piperidine 

Downstream Products

• 177947-85-2 5-{4-(benzylaminomethyl)piperidin-1-yl}pentanal dimethyl acetal 
• 177945-83-4 1-{3-[5-(1,2,4-Triazol-4-yl)-1H-indol-3-yl]propyl}-4-[(benzylamino)methyl]piperidine 
• 177945-85-6 1-{3-[5-(1,2,4-Triazol-4-yl)-1H-indol-3-yl]propyl}-4-[(N-benzyl-N-methylamino)methyl]piperidine 

Relevant articles and documents

Facile reduction of amides using nickel catalysis: Reduction of 12-aminododecanolactam

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3-[3-(piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists

Several 5-HT(ID/1B) receptor agonists are now entering the marketplace as treatments for migraine. This paper describes the development of selective h5-HT(1D)receptor agonists as potential antimigraine agents which may produce fewer side effects. A series of 3-[3-(piperidin-1-yl)propyl]indoles has been synthesized which has led to the identification of 80 (L-772,405), a high- affinity h5-HT(1D) receptor full agonist having 170-fold selectivity for h5- HT(1D) receptors over h5-HT(1B) receptors. L-772,405 also shows very good selectivity over a range of other serotonin and nonserotonin receptors and has excellent bioavailability following subcutaneous administration in rats. It therefore constitutes a valuable tool to delineate the role of h5-HT(1D) receptors in migraine. Molecular modeling and physical properties have been utilized to postulate the binding conformation of these compounds in the receptor cavity.