177957-65-2Relevant academic research and scientific papers
Total synthesis of an enantiomeric pair of FR900482. 1. Synthetic and end-game strategies
Katoh, Tadashi,Itoh, Etsuko,Yoshino, Toshiharu,Terashima, Shiro
, p. 10229 - 10238 (2007/10/03)
A synthetic strategy for an enantiomeric pair of FR900482 (1) was developed, which features a convergent and enantioselective sequence starting from 5-hydroxyisophthalic acid (16) and each enantiomer of diethyl tartrate (17 and ent-17). The proposed key intermediate 10 was synthesized from FK973 (3), the triacetyl derivative of 1, and successful reconversion of 10 into 1 was also achieved. These preliminary studies definitely demonstrated that 10 is suitable as a potential advanced key intermediate for 1 and that the crucial final sequence of reactions (10→1) involving delicate deprotection and oxidation steps can be realized.
Total synthesis of natural (+)-FR900482. 1. Synthetic and end-game strategies
Katoh, Tadashi,Itoh, Etsuko,Yoshino, Toshiharu,Terashima, Shiro
, p. 3471 - 3474 (2007/10/03)
A synthetic strategy for natural (+)-FR900482 (1) was developed by featuring a convergent and enantioselective sequence which commences with 5-hydroxyisophthalic acid and L-diethyl tartrate. The proposed key intermediate 4 was synthesized starting from FK
