1779899-46-5

Basic information

• Product Name: C₁₂H₂₁NO₄
• CAS NO: 1779899-46-5
• Molecular Weight: 243.303
• Mol File: 1779899-46-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: C₁₂H₂₁NO₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₂₁NO₄(1779899-46-5)
• EPA Substance Registry System: C₁₂H₂₁NO₄(1779899-46-5)

Safety Data

• Hazardous Substances Data: 1779899-46-5(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 55314-57-3 ethyl pent-2-ynoate 
• 114214-49-2 1-tert-butoxycarbonyl-3,4-epoxypyrrolidine 
• 73286-70-1 N-(tert-butoxycarbonyl)-3-pyrroline 
• 51814-19-8 1-Benzyloxycarbonyl-4-ethoxycarbonyl-3-oxopyrrolidine 

Downstream Products

• 1310726-60-3 (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide 
• 1428243-26-8 (3R,4S)-benzyl 3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate 
• 1428243-27-9 (3R,4S)-benzyl 3-(2-(tert-butoxycarbonyl(5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)amino)acetyl)-4-ethylpyrrolidine-1-carboxylate 

Relevant articles and documents

Method for synthesizing upadacitinib intermediate and the intermediate

The invention discloses a method for synthesizing upadacitinib intermediate. The method includes performing a ring-forming reaction with 2-pentynoate and N-(methoxymethyl)-N-(trimethylsilylmethyl)benzylamine under a catalyst A to prepare a compound (3), by which the compound (7) or the compound (8) can be obtained in various manners. The method especially the first and the third technical schemes,is high in yield and purity and is high in overall yield. The method is simple in post-treatment and is suitable for industrial large-scale production.

Synthesis method of JAK inhibitor intermediates

The invention discloses a synthesis method of JAK inhibitor intermediates. The method comprises the steps that a compound (2) serves as the raw material and reacts with ethylboric acid in the presenceof a catalyst, sodium phosphate and a phase transfer ca

NOVEL COMPOUNDS

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.